Component
2-Oxo-DIM / 3-((1H-indol-3-yl)methyl)indolin-2-one
2-Oxo-DIM / 3-((1H-indol-3-yl)methyl)indolin-2-one. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The identified 2-oxo-DIM product showed greater potency and efficacy than parent DIM in a Hepa1 AhR reporter assay.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"}
- experimental_model
- Human serial plasma/urine mass spectrometry and reporter assays
- exposure
- Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule
- limitations
- Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- Seven adults; mouse Hepa1 reporter cells
- plain_language
- A metabolite can signal more strongly than the compound that produced it.
- primary_references
- [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
- tissue_or_cell_type
- DIM metabolism and metabolite signaling
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 246–257
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human serial plasma/urine mass spectrometry and reporter assays · source_derived_draft · unverified_draft
### dim-dim-metabolite-ahr The identified 2-oxo-DIM product showed greater potency and efficacy than parent DIM in a Hepa1 AhR reporter assay. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A metabolite can signal more strongly than the compound that produced it. organism: Seven adults; mouse Hepa1 reporter cells tissue_or_cell_type: DIM metabolism and metabolite signaling experimental_model: Human serial plasma/urine mass spectrometry and reporter assays limitations: Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response. exposure: Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule evidence_span: {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"} [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.