Component
Mouse interleukin-22 / Il22
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
IL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse fungal colonization and mucosal inflammation models.
- limitations
- This protective model does not establish a universally beneficial effect of sustained AHR or IL-22 activation.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- The downstream cytokine helped organize mucosal defense.
- primary_references
- Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 482–488
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse fungal colonization and mucosal inflammation models. · source_derived_draft · unverified_draft
## tryptophan-il22-protection The downstream cytokine helped organize mucosal defense. IL-22-dependent mucosal responses supported Candida colonization resistance and protection from inflammation in the mouse microbial-tryptophan study. Model: Mouse fungal colonization and mucosal inflammation models. Limitations: This protective model does not establish a universally beneficial effect of sustained AHR or IL-22 activation. Evidence access: Primary abstract Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003
Complete structured claim and evidence
What acts on it
Microbial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse mucosal immunity and microbial metabolite experiments.
- limitations
- Not a direct human supplementation outcome.
- nutrient_topic
- Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
- plain_language
- A microbial product connected the amino acid to an epithelial-defense cytokine.
- primary_references
- Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003
Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 474–480
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse mucosal immunity and microbial metabolite experiments. · source_derived_draft · unverified_draft
## tryptophan-aldehyde-ahr A microbial product connected the amino acid to an epithelial-defense cytokine. Microbial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice. Model: Mouse mucosal immunity and microbial metabolite experiments. Limitations: Not a direct human supplementation outcome. Evidence access: Primary abstract Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.