{"id":"19f36e0b-ba9c-55f4-9c29-b855a89bb141","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-aldehyde-ahr","predicate":"supports_receptor_dependent_expression","statement":"Microbial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5589ec67-b7c1-589c-a3fb-ea9f0d58f1bf","mechanism_event_label":"A microbial product connected the amino acid to an epithelial-defense cytokine.","subject":{"id":"3848aa02-353b-5f20-a28e-e424d6efdb8a","slug":"indole-3-aldehyde","display_name":"Indole-3-aldehyde","entity_type_key":"small_molecule"},"object":{"id":"7da9efbe-a654-57be-bfbd-6b5eba3794c8","slug":"mouse-il22","display_name":"Mouse interleukin-22 / Il22","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"5589ec67-b7c1-589c-a3fb-ea9f0d58f1bf","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-aldehyde-ahr-event","event_type":"observed_relationship","label":"A microbial product connected the amino acid to an epithelial-defense cytokine.","description":"Microbial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3848aa02-353b-5f20-a28e-e424d6efdb8a","slug":"indole-3-aldehyde","display_name":"Indole-3-aldehyde","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7da9efbe-a654-57be-bfbd-6b5eba3794c8","slug":"mouse-il22","display_name":"Mouse interleukin-22 / Il22","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"af2dbfd7-6b48-5f35-b6ff-15c0a1e24aa9","slug":"mouse-ahr","display_name":"Mouse aryl hydrocarbon receptor / Ahr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse mucosal immunity and microbial metabolite experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a direct human supplementation outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A microbial product connected the amino acid to an epithelial-defense cytokine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c37a96e9-ca7b-5b18-8af4-28bb3b65f6df","evidence_kind":"source_excerpt","locator":"Lines 474-480","start_line":474,"end_line":480,"excerpt":"## tryptophan-aldehyde-ahr\nA microbial product connected the amino acid to an epithelial-defense cytokine.\nMicrobial indole-3-aldehyde supported Ahr-dependent Il22 transcription in mice.\nModel: Mouse mucosal immunity and microbial metabolite experiments.\nLimitations: Not a direct human supplementation outcome.\nEvidence access: Primary abstract\nTryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23973224/ · DOI 10.1016/j.immuni.2013.08.003","model_system":"Mouse mucosal immunity and microbial metabolite experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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