Component
Intestinal calcium absorption
Independent cellular process record; interpretation is limited by each linked claim and its study context.
11 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Calcitriol administration increased active duodenal calcium transport in vitamin-D-deficient wild-type mice in the Benn study.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Vitamin D–calcium–phosphate regulation.
- evidence_locator
- Abstract: reported experimental results
- evidence_scope
- D3 active metabolite or VDR machinery experiment; not a direct D2-versus-D3 comparison.
- experimental_model
- Vitamin-D-deficient wild-type mice; everted duodenal gut-sac calcium transport
- exposure
- Diet-induced vitamin D deficiency followed by calcitriol administration; exact replacement dose/time not reported in the retrieved abstract.
- limitations
- Wild-type arm is separated from the knockout arms; this is active-hormone replacement, not a D2/D3 oral-dose equivalence test.
- nutrient
- Vitamin D2 and D3 · Vitamin D2 and D3
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Mus musculus
- plain_language
- Providing the active hormone restored part of the intestinal calcium-transport response after vitamin D deprivation.
- primary_references
- [vdm-benn2008] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. (2008). https://pubmed.ncbi.nlm.nih.gov/18325990/ DOI: 10.1210/en.2007-1655
- tissue_or_cell_type
- Duodenum
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 649–663
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Vitamin-D-deficient wild-type mice; everted duodenal gut-sac calcium transport · source_derived_draft · unverified_draft
### vdm-calcitriol-restores-transport-after-d-deficiency Calcitriol administration increased active duodenal calcium transport in vitamin-D-deficient wild-type mice in the Benn study. Condition category: nutrient_deficiency nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Providing the active hormone restored part of the intestinal calcium-transport response after vitamin D deprivation. organism: Mus musculus tissue_or_cell_type: Duodenum experimental_model: Vitamin-D-deficient wild-type mice; everted duodenal gut-sac calcium transport limitations: Wild-type arm is separated from the knockout arms; this is active-hormone replacement, not a D2/D3 oral-dose equivalence test. exposure: Diet-induced vitamin D deficiency followed by calcitriol administration; exact replacement dose/time not reported in the retrieved abstract. cross_nutrient: Vitamin D–calcium–phosphate regulation. evidence_locator: Abstract: reported experimental results nutrient: Vitamin D2 and D3 evidence_scope: D3 active metabolite or VDR machinery experiment; not a direct D2-versus-D3 comparison. [vdm-benn2008] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. (2008). https://pubmed.ncbi.nlm.nih.gov/18325990/ DOI: 10.1210/en.2007-1655
Complete structured claim and evidenceFasting achlorhydric participants absorbed substantially less calcium from carbonate than from citrate.
Experimental context and source evidence
- experimental_model
- 11 achlorhydric patients and nine controls; 250 mg calcium isotope tests.
- exposure
- Fasting achlorhydric mean fractions: carbonate 0.042, citrate 0.452; normal subjects showed no significant formulation difference.
- limitations
- Not evidence that carbonate always fails or citrate always outperforms it.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- Low stomach acid can change how a calcium preparation is absorbed.
- primary_references
- [cal-clin-recker1985] Calcium absorption and achlorhydria (1985). https://pubmed.ncbi.nlm.nih.gov/4000241/ DOI: 10.1056/NEJM198507113130202
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1164–1174
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 11 achlorhydric patients and nine controls; 250 mg calcium isotope tests. · source_derived_draft · unverified_draft
### cal-carbonate-fasting-achlorhydria Fasting achlorhydric participants absorbed substantially less calcium from carbonate than from citrate. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low stomach acid can change how a calcium preparation is absorbed. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 11 achlorhydric patients and nine controls; 250 mg calcium isotope tests. limitations: Not evidence that carbonate always fails or citrate always outperforms it. exposure: Fasting achlorhydric mean fractions: carbonate 0.042, citrate 0.452; normal subjects showed no significant formulation difference. [cal-clin-recker1985] Calcium absorption and achlorhydria (1985). https://pubmed.ncbi.nlm.nih.gov/4000241/ DOI: 10.1056/NEJM198507113130202
Complete structured claim and evidenceCalcium carbonate given with a normal breakfast showed normal absorption in the achlorhydric participants.
Experimental context and source evidence
- experimental_model
- Meal comparison in the achlorhydria absorption study.
- limitations
- Small study; the meal experiment did not isolate a molecular rescue mechanism.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- The meal changed the result seen during fasting.
- primary_references
- [cal-clin-recker1985] Calcium absorption and achlorhydria (1985). https://pubmed.ncbi.nlm.nih.gov/4000241/ DOI: 10.1056/NEJM198507113130202
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1176–1185
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Meal comparison in the achlorhydria absorption study. · source_derived_draft · unverified_draft
### cal-carbonate-meal-achlorhydria Calcium carbonate given with a normal breakfast showed normal absorption in the achlorhydric participants. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The meal changed the result seen during fasting. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: Meal comparison in the achlorhydria absorption study. limitations: Small study; the meal experiment did not isolate a molecular rescue mechanism. [cal-clin-recker1985] Calcium absorption and achlorhydria (1985). https://pubmed.ncbi.nlm.nih.gov/4000241/ DOI: 10.1056/NEJM198507113130202
Complete structured claim and evidenceCalcium absorption from the tested spinach meal was lower than from milk at equal calcium load.
Experimental context and source evidence
- experimental_model
- 13-adult crossover; 200 mg calcium per test meal, double-isotope measurement.
- exposure
- Mean fractional absorption: spinach 5.1%, milk 27.6%; oxalate slightly exceeded calcium stoichiometrically in tested spinach.
- limitations
- Food-matrix comparison; oxalate binding was inferred from composition, not isolated experimentally. Not a comparison of every plant food.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- Equal calcium on a food label need not mean equal absorption.
- primary_references
- [cal-clin-heaney1988] Calcium absorbability from spinach (1988). https://pubmed.ncbi.nlm.nih.gov/3354496/ DOI: 10.1093/ajcn/47.4.707
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1152–1162
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 13-adult crossover; 200 mg calcium per test meal, double-isotope measurement. · source_derived_draft · unverified_draft
### cal-food-spinach-absorption Calcium absorption from the tested spinach meal was lower than from milk at equal calcium load. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Equal calcium on a food label need not mean equal absorption. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: 13-adult crossover; 200 mg calcium per test meal, double-isotope measurement. limitations: Food-matrix comparison; oxalate binding was inferred from composition, not isolated experimentally. Not a comparison of every plant food. exposure: Mean fractional absorption: spinach 5.1%, milk 27.6%; oxalate slightly exceeded calcium stoichiometrically in tested spinach. [cal-clin-heaney1988] Calcium absorbability from spinach (1988). https://pubmed.ncbi.nlm.nih.gov/3354496/ DOI: 10.1093/ajcn/47.4.707
Complete structured claim and evidenceIntestinal Atp2b1 deletion prevented the active-calcium-transport increase elicited by calcitriol in control mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Villin-Cre intestine-specific Atp2b1 deletion in mice
- limitations
- Conditional deletion and administered calcitriol; basal absorption was not shown to be zero.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Mus musculus
- plain_language
- A calcium pump is needed for this hormone response.
- primary_references
- [ryan2015] Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3 (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4772868/ DOI: 10.1016/j.bbrc.2015.09.087
- tissue_or_cell_type
- Intestinal absorptive cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 280–289
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Villin-Cre intestine-specific Atp2b1 deletion in mice · source_derived_draft · unverified_draft
### intestinal-pmca1-loss-calcitriol-response Intestinal Atp2b1 deletion prevented the active-calcium-transport increase elicited by calcitriol in control mice. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A calcium pump is needed for this hormone response. organism: Mus musculus tissue_or_cell_type: Intestinal absorptive cells experimental_model: Villin-Cre intestine-specific Atp2b1 deletion in mice limitations: Conditional deletion and administered calcitriol; basal absorption was not shown to be zero. [ryan2015] Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3 (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4772868/ DOI: 10.1016/j.bbrc.2015.09.087
Complete structured claim and evidenceTrpv5-null mice show increased intestinal absorption of orally administered calcium tracer.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Trpv5 knockout mice; renal micropuncture and oral calcium tracer assays
- limitations
- Compensation accompanies renal loss; not direct intestinal TRPV5 transport.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Mus musculus
- plain_language
- Gut uptake compensates for kidney losses.
- primary_references
- [hoenderop2003] Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5 (2003). https://pmc.ncbi.nlm.nih.gov/articles/PMC297001/ DOI: 10.1172/JCI19826
- tissue_or_cell_type
- Intestine
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 247–256
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Trpv5 knockout mice; renal micropuncture and oral calcium tracer assays · source_derived_draft · unverified_draft
### trpv5-loss-compensatory-intestinal-absorption Trpv5-null mice show increased intestinal absorption of orally administered calcium tracer. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Gut uptake compensates for kidney losses. organism: Mus musculus tissue_or_cell_type: Intestine experimental_model: Trpv5 knockout mice; renal micropuncture and oral calcium tracer assays limitations: Compensation accompanies renal loss; not direct intestinal TRPV5 transport. [hoenderop2003] Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5 (2003). https://pmc.ncbi.nlm.nih.gov/articles/PMC297001/ DOI: 10.1172/JCI19826
Complete structured claim and evidenceSignificant active duodenal calcium transport persists in Trpv6/calbindin-D9k double-null mice under the tested stimulation conditions.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Trpv6 and calbindin-D9k single/double knockout mice; duodenal transport assays
- limitations
- Residual transport does not establish dispensability under every diet or life stage.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Mus musculus
- plain_language
- Other routes can support active calcium absorption.
- primary_references
- [benn2008] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2408805/ DOI: 10.1210/en.2007-1655
- reported_effect
- retained
- tissue_or_cell_type
- Duodenum
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 169–179
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Trpv6 and calbindin-D9k single/double knockout mice; duodenal transport assays · source_derived_draft · unverified_draft
### trpv6-calbindin-independent-active-transport Significant active duodenal calcium transport persists in Trpv6/calbindin-D9k double-null mice under the tested stimulation conditions. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Other routes can support active calcium absorption. organism: Mus musculus tissue_or_cell_type: Duodenum experimental_model: Trpv6 and calbindin-D9k single/double knockout mice; duodenal transport assays limitations: Residual transport does not establish dispensability under every diet or life stage. reported_effect: retained [benn2008] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2408805/ DOI: 10.1210/en.2007-1655
Complete structured claim and evidenceTrpv6 deletion reduced intestinal calcium absorption by about 60% in the Bianco mouse model.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Whole-body Trpv6 knockout mice under regular and low-calcium diets
- limitations
- Whole-body deletion; diet and assay matter; residual absorption remained.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Mus musculus
- plain_language
- TRPV6 materially supports calcium uptake in this model.
- primary_references
- [bianco2007] Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene (2007). https://pubmed.ncbi.nlm.nih.gov/17129178/ DOI: 10.1359/jbmr.061110
- tissue_or_cell_type
- Intestine
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 158–167
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body Trpv6 knockout mice under regular and low-calcium diets · source_derived_draft · unverified_draft
### trpv6-loss-reduces-absorption Trpv6 deletion reduced intestinal calcium absorption by about 60% in the Bianco mouse model. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: TRPV6 materially supports calcium uptake in this model. organism: Mus musculus tissue_or_cell_type: Intestine experimental_model: Whole-body Trpv6 knockout mice under regular and low-calcium diets limitations: Whole-body deletion; diet and assay matter; residual absorption remained. [bianco2007] Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene (2007). https://pubmed.ncbi.nlm.nih.gov/17129178/ DOI: 10.1359/jbmr.061110
Complete structured claim and evidenceAdding lysine plus arginine to a low-protein diet produced only a nonsignificant calcium-absorption trend: 25.2% versus 22.3% with control, P=0.094.
Experimental context and source evidence
- experimental_model
- Six-day randomized crossover feeding study in 14 women
- limitations
- Combined amino acids; small sample; specifically low-protein background diet; no long-term skeletal endpoint.
- organism
- Homo sapiens
- plain_language
- The trial did not establish a statistically significant absorption benefit.
- primary_references
- [bihuniak2014] Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3927545/ DOI: 10.3945/jn.113.185009
- tissue_or_cell_type
- Intestine
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 769–777
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-day randomized crossover feeding study in 14 women · source_derived_draft · unverified_draft
### dibasic-calcium-absorption-trend Adding lysine plus arginine to a low-protein diet produced only a nonsignificant calcium-absorption trend: 25.2% versus 22.3% with control, P=0.094. Plain language: The trial did not establish a statistically significant absorption benefit. Condition category: normal organism: Homo sapiens tissue_or_cell_type: Intestine experimental_model: Six-day randomized crossover feeding study in 14 women limitations: Combined amino acids; small sample; specifically low-protein background diet; no long-term skeletal endpoint. [bihuniak2014] Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3927545/ DOI: 10.3945/jn.113.185009
Complete structured claim and evidenceIn a short-term study of osteoporotic patients, lysine supplementation increased measured calcium absorption, whereas the valine and tryptophan comparators did not.
Experimental context and source evidence
- experimental_model
- Amino-acid comparator experiment using 800 mg/day in 45 osteoporotic patients
- limitations
- Short-term mineral handling; no fracture prevention or bone-density benefit established.
- organism
- Homo sapiens
- plain_language
- A small experiment found better absorption of calcium.
- primary_references
- [civitelli1992] Dietary L-lysine and calcium metabolism in humans (1992). https://pubmed.ncbi.nlm.nih.gov/1486246/
- tissue_or_cell_type
- Intestine
L-Lysine: mechanism-first literature curation (2026-09-17) · lines 749–757
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Amino-acid comparator experiment using 800 mg/day in 45 osteoporotic patients · source_derived_draft · unverified_draft
### lysine-calcium-intestinal-study In a short-term study of osteoporotic patients, lysine supplementation increased measured calcium absorption, whereas the valine and tryptophan comparators did not. Plain language: A small experiment found better absorption of calcium. Condition category: normal organism: Homo sapiens tissue_or_cell_type: Intestine experimental_model: Amino-acid comparator experiment using 800 mg/day in 45 osteoporotic patients limitations: Short-term mineral handling; no fracture prevention or bone-density benefit established. [civitelli1992] Dietary L-lysine and calcium metabolism in humans (1992). https://pubmed.ncbi.nlm.nih.gov/1486246/
Complete structured claim and evidenceApparent calcium absorption was unchanged in the ileostomy study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/pectin-research/6307932.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1", "start_char": 0, "end_char": 1593, "text_sha256": "fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1"}
- experimental_model
- Within-person ileostomy balance study; six participants
- exposure
- 15 g/day citrus pectin on days 5-7 of a 10-day low-fiber feeding protocol
- limitations
- Ileal apparent absorption and output are not whole-body status or clinical deficiency; the colon was bypassed.
- nutrient_topic
- Pectin research collection; topical membership is not evidence of a direct dietary effect. · Pectin, structurally heterogeneous plant polysaccharides
- organism
- Homo sapiens
- plain_language
- The effect on iron did not extend to every mineral.
- primary_references
- [pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. (1983). https://pubmed.ncbi.nlm.nih.gov/6307932/
- tissue_or_cell_type
- Small intestine; ileal effluent
Pectin: metabolism, signaling and nutrient connections (2026-09-17) · lines 607–618
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Within-person ileostomy balance study; six participants · source_derived_draft · unverified_draft
### pectin-ileal-calcium-null Apparent calcium absorption was unchanged in the ileostomy study. Condition category: normal nutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The effect on iron did not extend to every mineral. organism: Homo sapiens tissue_or_cell_type: Small intestine; ileal effluent experimental_model: Within-person ileostomy balance study; six participants limitations: Ileal apparent absorption and output are not whole-body status or clinical deficiency; the colon was bypassed. exposure: 15 g/day citrus pectin on days 5-7 of a 10-day low-fiber feeding protocol evidence_span: {"source_cache": "artifacts/pectin-research/6307932.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1", "start_char": 0, "end_char": 1593, "text_sha256": "fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1"} [pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. (1983). https://pubmed.ncbi.nlm.nih.gov/6307932/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.