Component

TRPV6

Independent biological entity. Read linked claims for experimental scope and context.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Rat CaT1, now termed TRPV6, mediates electrogenic calcium uptake when expressed in Xenopus oocytes.

    TRPV6 → Calcium ion source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Rat duodenal CaT1/TRPV6 expression in Xenopus oocytes; uptake and electrophysiology
    limitations
    Heterologous uptake is not proof that every intestinal calcium ion uses this channel.
    nutrient_topic
    Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
    organism
    Rattus norvegicus channel in Xenopus laevis
    plain_language
    TRPV6 permits calcium entry across a membrane.
    primary_references
    [peng1999] Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption (1999). https://pubmed.ncbi.nlm.nih.gov/10428857/ DOI: 10.1074/jbc.274.32.22739
    tissue_or_cell_type
    Plasma membrane; duodenal channel origin
    transport_effect
    raises Mediates electrogenic calcium uptake when expressed.
    transport_or_reaction_direction
    inward
    transport_pool
    cytosolic calcium Mediates electrogenic calcium uptake when expressed.

    Calcium: mechanism-first literature curation (2026-09-17) · lines 387–397

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat duodenal CaT1/TRPV6 expression in Xenopus oocytes; uptake and electrophysiology · source_derived_draft · unverified_draft

    ### trpv6-direct-calcium-permeation Rat CaT1, now termed TRPV6, mediates electrogenic calcium uptake when expressed in Xenopus oocytes. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: TRPV6 permits calcium entry across a membrane. organism: Rattus norvegicus channel in Xenopus laevis tissue_or_cell_type: Plasma membrane; duodenal channel origin experimental_model: Rat duodenal CaT1/TRPV6 expression in Xenopus oocytes; uptake and electrophysiology limitations: Heterologous uptake is not proof that every intestinal calcium ion uses this channel. transport_or_reaction_direction: inward [peng1999] Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption (1999). https://pubmed.ncbi.nlm.nih.gov/10428857/ DOI: 10.1074/jbc.274.32.22739
    Complete structured claim and evidence

  2. Trpv6 deletion reduced intestinal calcium absorption by about 60% in the Bianco mouse model.

    TRPV6 → Intestinal calcium absorption source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Whole-body Trpv6 knockout mice under regular and low-calcium diets
    limitations
    Whole-body deletion; diet and assay matter; residual absorption remained.
    nutrient_topic
    Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
    organism
    Mus musculus
    plain_language
    TRPV6 materially supports calcium uptake in this model.
    primary_references
    [bianco2007] Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene (2007). https://pubmed.ncbi.nlm.nih.gov/17129178/ DOI: 10.1359/jbmr.061110
    tissue_or_cell_type
    Intestine
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Calcium: mechanism-first literature curation (2026-09-17) · lines 158–167

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-body Trpv6 knockout mice under regular and low-calcium diets · source_derived_draft · unverified_draft

    ### trpv6-loss-reduces-absorption Trpv6 deletion reduced intestinal calcium absorption by about 60% in the Bianco mouse model. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: TRPV6 materially supports calcium uptake in this model. organism: Mus musculus tissue_or_cell_type: Intestine experimental_model: Whole-body Trpv6 knockout mice under regular and low-calcium diets limitations: Whole-body deletion; diet and assay matter; residual absorption remained. [bianco2007] Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene (2007). https://pubmed.ncbi.nlm.nih.gov/17129178/ DOI: 10.1359/jbmr.061110
    Complete structured claim and evidence

What acts on it

  1. Calcitriol induces human TRPV6 transcription through VDR/RXR-associated regulatory elements in intestinal cell models.

    Calcitriol → TRPV6 source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Human intestinal cell lines; chromatin immunoprecipitation, promoter reporters and regulatory-element mutagenesis
    limitations
    Promoter activity and receptor occupancy do not establish an exclusive transport route or whole-body calcium flux.
    nutrient_topic
    Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
    organism
    Homo sapiens cell lines
    plain_language
    Active vitamin D increases a calcium-entry channel.
    primary_references
    [meyer2006] The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells (2006). https://pubmed.ncbi.nlm.nih.gov/16574738/ DOI: 10.1210/me.2006-0031
    tissue_or_cell_type
    Intestinal cell transcriptional regulation

    Calcium: mechanism-first literature curation (2026-09-17) · lines 181–190

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human intestinal cell lines; chromatin immunoprecipitation, promoter reporters and regulatory-element mutagenesis · source_derived_draft · unverified_draft

    ### calcitriol-vdr-induces-trpv6 Calcitriol induces human TRPV6 transcription through VDR/RXR-associated regulatory elements in intestinal cell models. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Active vitamin D increases a calcium-entry channel. organism: Homo sapiens cell lines tissue_or_cell_type: Intestinal cell transcriptional regulation experimental_model: Human intestinal cell lines; chromatin immunoprecipitation, promoter reporters and regulatory-element mutagenesis limitations: Promoter activity and receptor occupancy do not establish an exclusive transport route or whole-body calcium flux. [meyer2006] The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells (2006). https://pubmed.ncbi.nlm.nih.gov/16574738/ DOI: 10.1210/me.2006-0031
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Significant active duodenal calcium transport persists in Trpv6/calbindin-D9k double-null mice under the tested stimulation conditions.

    TRPV6 and calbindin-D9k → Intestinal calcium absorption source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    experimental_model
    Trpv6 and calbindin-D9k single/double knockout mice; duodenal transport assays
    limitations
    Residual transport does not establish dispensability under every diet or life stage.
    nutrient_topic
    Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
    organism
    Mus musculus
    plain_language
    Other routes can support active calcium absorption.
    primary_references
    [benn2008] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2408805/ DOI: 10.1210/en.2007-1655
    reported_effect
    retained
    tissue_or_cell_type
    Duodenum
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Calcium: mechanism-first literature curation (2026-09-17) · lines 169–179

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Trpv6 and calbindin-D9k single/double knockout mice; duodenal transport assays · source_derived_draft · unverified_draft

    ### trpv6-calbindin-independent-active-transport Significant active duodenal calcium transport persists in Trpv6/calbindin-D9k double-null mice under the tested stimulation conditions. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Other routes can support active calcium absorption. organism: Mus musculus tissue_or_cell_type: Duodenum experimental_model: Trpv6 and calbindin-D9k single/double knockout mice; duodenal transport assays limitations: Residual transport does not establish dispensability under every diet or life stage. reported_effect: retained [benn2008] Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2408805/ DOI: 10.1210/en.2007-1655
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards