{"id":"b3997e06-8376-56b3-91bb-e04f9b37a7f0","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:calcitriol-vdr-induces-trpv6","predicate":"increases_expression","statement":"Calcitriol induces human TRPV6 transcription through VDR/RXR-associated regulatory elements in intestinal cell models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7f41ce50-d1e8-5ea5-8fc7-3a0fe4e1b496","mechanism_event_label":"Active vitamin D increases a calcium-entry channel.","subject":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"object":{"id":"2f5ca870-de94-5d5e-a9f6-d8da99e26360","slug":"trpv6","display_name":"TRPV6","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7f41ce50-d1e8-5ea5-8fc7-3a0fe4e1b496","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:calcitriol-vdr-induces-trpv6-event","event_type":"biochemical_relationship","label":"Active vitamin D increases a calcium-entry channel.","description":"Calcitriol induces human TRPV6 transcription through VDR/RXR-associated regulatory elements in intestinal cell models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f5156c24-108f-5746-b114-ed764e79a3f4","slug":"calcitriol","display_name":"Calcitriol","entity_type_key":"small_molecule"},"role":"hormonal_regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d725020b-bacc-5e90-b370-cda246025c91","slug":"vdr","display_name":"Vitamin D receptor / VDR","entity_type_key":"protein"},"role":"transcriptional_receptor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2f5ca870-de94-5d5e-a9f6-d8da99e26360","slug":"trpv6","display_name":"TRPV6","entity_type_key":"protein"},"role":"regulated_channel","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Human intestinal cell lines; chromatin immunoprecipitation, promoter reporters and regulatory-element mutagenesis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Promoter activity and receptor occupancy do not establish an exclusive transport route or whole-body calcium flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens cell lines","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Active vitamin D increases a calcium-entry channel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[meyer2006] The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells (2006). https://pubmed.ncbi.nlm.nih.gov/16574738/ DOI: 10.1210/me.2006-0031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal cell transcriptional regulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"edd2ef3c-48fd-5b1c-bd61-0d9dd2b290ee","evidence_kind":"source_excerpt","locator":"Lines 181-190","start_line":181,"end_line":190,"excerpt":"### calcitriol-vdr-induces-trpv6\nCalcitriol induces human TRPV6 transcription through VDR/RXR-associated regulatory elements in intestinal cell models.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Active vitamin D increases a calcium-entry channel.\norganism: Homo sapiens cell lines\ntissue_or_cell_type: Intestinal cell transcriptional regulation\nexperimental_model: Human intestinal cell lines; chromatin immunoprecipitation, promoter reporters and regulatory-element mutagenesis\nlimitations: Promoter activity and receptor occupancy do not establish an exclusive transport route or whole-body calcium flux.\n[meyer2006] The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells (2006). https://pubmed.ncbi.nlm.nih.gov/16574738/ DOI: 10.1210/me.2006-0031","model_system":"Human intestinal cell lines; chromatin immunoprecipitation, promoter reporters and regulatory-element mutagenesis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [meyer2006] The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells (2006). https://pubmed.ncbi.nlm.nih.gov/16574738/ DOI: 10.1210/me.2006-0031","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}