{"id":"8937ce95-2c79-5919-8e64-4787bea6fdac","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:dibasic-calcium-absorption-trend","predicate":"with_arginine_showed_nonsignificant_trend_in","statement":"Adding lysine plus arginine to a low-protein diet produced only a nonsignificant calcium-absorption trend: 25.2% versus 22.3% with control, P=0.094.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"becf305e-b1cf-5008-9c03-2d7dabc8e996","mechanism_event_label":"The trial did not establish a statistically significant absorption benefit.","subject":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"object":{"id":"53d44ad2-3648-5c31-8328-bcc1344961df","slug":"intestinal-calcium-absorption","display_name":"Intestinal calcium absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"becf305e-b1cf-5008-9c03-2d7dabc8e996","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:dibasic-calcium-absorption-trend-event","event_type":"observed_intervention","label":"The trial did not establish a statistically significant absorption benefit.","description":"Adding lysine plus arginine to a low-protein diet produced only a nonsignificant calcium-absorption trend: 25.2% versus 22.3% with control, P=0.094.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"53d44ad2-3648-5c31-8328-bcc1344961df","slug":"intestinal-calcium-absorption","display_name":"Intestinal calcium absorption","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"absorbed_ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Six-day randomized crossover feeding study in 14 women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Combined amino acids; small sample; specifically low-protein background diet; no long-term skeletal endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial did not establish a statistically significant absorption benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[bihuniak2014] Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3927545/ DOI: 10.3945/jn.113.185009","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6befeb1b-6236-5b25-9179-f9438b20afa2","evidence_kind":"source_excerpt","locator":"Lines 769-777","start_line":769,"end_line":777,"excerpt":"### dibasic-calcium-absorption-trend\nAdding lysine plus arginine to a low-protein diet produced only a nonsignificant calcium-absorption trend: 25.2% versus 22.3% with control, P=0.094.\nPlain language: The trial did not establish a statistically significant absorption benefit.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Intestine\nexperimental_model: Six-day randomized crossover feeding study in 14 women\nlimitations: Combined amino acids; small sample; specifically low-protein background diet; no long-term skeletal endpoint.\n[bihuniak2014] Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3927545/ DOI: 10.3945/jn.113.185009","model_system":"Six-day randomized crossover feeding study in 14 women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [bihuniak2014] Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women (2014). https://pmc.ncbi.nlm.nih.gov/articles/PMC3927545/ DOI: 10.3945/jn.113.185009","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}