Component
Plasma membrane calcium ATPase 1 / ATP2B1
Independent biological entity. Read linked claims for experimental scope and context.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human PMCA1 is an ATP-driven plasma-membrane calcium extrusion pump characterized structurally with neuroplastin.
Experimental context and source evidence
- compartment_description
- Plasma membrane
- experimental_model
- Purified human PMCA1-neuroplastin complex; cryo-EM and ATPase assays
- limitations
- This study combines structure and ATPase assays; it does not quantify whole-tissue extrusion flux.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- PMCA1 uses ATP to clear calcium from the cytosol.
- primary_references
- [ca-gong2018] Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin (2018). https://pubmed.ncbi.nlm.nih.gov/30190470/ DOI: 10.1038/s41467-018-06075-7
- research_relationship_category
- transport
- tissue_or_cell_type
- Purified recombinant pump
- transport_effect
- lowers Recorded as an ATP-driven plasma-membrane calcium extrusion pump.
- transport_or_reaction_direction
- Cytosol to extracellular fluid
- transport_pool
- cytosolic calcium Recorded as an ATP-driven plasma-membrane calcium extrusion pump.
Calcium: mechanism-first literature curation (2026-09-17) · lines 585–597
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human PMCA1-neuroplastin complex; cryo-EM and ATPase assays · source_derived_draft · unverified_draft
### ca-pmca1-extrusion Human PMCA1 is an ATP-driven plasma-membrane calcium extrusion pump characterized structurally with neuroplastin. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: PMCA1 uses ATP to clear calcium from the cytosol. organism: Homo sapiens tissue_or_cell_type: Purified recombinant pump experimental_model: Purified human PMCA1-neuroplastin complex; cryo-EM and ATPase assays limitations: This study combines structure and ATPase assays; it does not quantify whole-tissue extrusion flux. research_relationship_category: transport transport_or_reaction_direction: Cytosol to extracellular fluid compartment_description: Plasma membrane [ca-gong2018] Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin (2018). https://pubmed.ncbi.nlm.nih.gov/30190470/ DOI: 10.1038/s41467-018-06075-7
Complete structured claim and evidenceIntestinal Atp2b1 deletion prevented the active-calcium-transport increase elicited by calcitriol in control mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Villin-Cre intestine-specific Atp2b1 deletion in mice
- limitations
- Conditional deletion and administered calcitriol; basal absorption was not shown to be zero.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Mus musculus
- plain_language
- A calcium pump is needed for this hormone response.
- primary_references
- [ryan2015] Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3 (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4772868/ DOI: 10.1016/j.bbrc.2015.09.087
- tissue_or_cell_type
- Intestinal absorptive cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Calcium: mechanism-first literature curation (2026-09-17) · lines 280–289
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Villin-Cre intestine-specific Atp2b1 deletion in mice · source_derived_draft · unverified_draft
### intestinal-pmca1-loss-calcitriol-response Intestinal Atp2b1 deletion prevented the active-calcium-transport increase elicited by calcitriol in control mice. Condition category: machinery_impairment nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A calcium pump is needed for this hormone response. organism: Mus musculus tissue_or_cell_type: Intestinal absorptive cells experimental_model: Villin-Cre intestine-specific Atp2b1 deletion in mice limitations: Conditional deletion and administered calcitriol; basal absorption was not shown to be zero. [ryan2015] Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3 (2015). https://pmc.ncbi.nlm.nih.gov/articles/PMC4772868/ DOI: 10.1016/j.bbrc.2015.09.087
Complete structured claim and evidence
What acts on it
Neuroplastin binds the transmembrane region of human PMCA1 and supports pump ATPase activity.
Experimental context and source evidence
- compartment_description
- Plasma membrane protein complex
- experimental_model
- Purified human PMCA1-neuroplastin complex; cryo-EM and ATPase assays
- limitations
- Purified PMCA1 complex; subunit availability and other PMCA isoforms require separate evidence.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- Neuroplastin helps PMCA1 function.
- primary_references
- [ca-gong2018] Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin (2018). https://pubmed.ncbi.nlm.nih.gov/30190470/ DOI: 10.1038/s41467-018-06075-7
- research_relationship_category
- regulation
- tissue_or_cell_type
- Purified recombinant proteins
Calcium: mechanism-first literature curation (2026-09-17) · lines 599–610
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human PMCA1-neuroplastin complex; cryo-EM and ATPase assays · source_derived_draft · unverified_draft
### ca-neuroplastin-pmca1-support Neuroplastin binds the transmembrane region of human PMCA1 and supports pump ATPase activity. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Neuroplastin helps PMCA1 function. organism: Homo sapiens tissue_or_cell_type: Purified recombinant proteins experimental_model: Purified human PMCA1-neuroplastin complex; cryo-EM and ATPase assays limitations: Purified PMCA1 complex; subunit availability and other PMCA isoforms require separate evidence. research_relationship_category: regulation compartment_description: Plasma membrane protein complex [ca-gong2018] Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin (2018). https://pubmed.ncbi.nlm.nih.gov/30190470/ DOI: 10.1038/s41467-018-06075-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.