Component

Urinary pantothenate excretion

Urinary pantothenate excretion. Experimental scope belongs to the associated record.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. In the elderly cohort, free pantothenic acid was detected in urine, whereas the measured phosphoderivative fraction was not; microbiological and radioimmunoassay estimates correlated at r=0.91.

    Urinary pantothenate excretion → Pantothenate (vitamin B5) source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary indexed abstract.
    experimental_model
    Observational study of 91 adults aged at least 65, including institutionalized and community participants
    exposure
    Microbiological and radioimmunoassay analyses of free and derivative pantothenate fractions.
    limitations
    Assay-specific findings; urinary free pantothenate is distinct from intracellular CoA and its acyl derivatives.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    The urinary assay mostly described free vitamin, not the cell’s activated CoA pool.
    primary_references
    [b5-clin-tarr1981] Pantothenic acid nutritional status in the elderly--institutionalized and noninstitutionalized. (1981). https://pubmed.ncbi.nlm.nih.gov/7025609/ DOI: 10.1093/ajcn/34.9.1736
    tissue_or_cell_type
    Fasting blood, 24-hour urine and seven-day diet records
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1313–1325

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Observational study of 91 adults aged at least 65, including institutionalized and community participants · source_derived_draft · unverified_draft

    ### b5-clin-urinary-species In the elderly cohort, free pantothenic acid was detected in urine, whereas the measured phosphoderivative fraction was not; microbiological and radioimmunoassay estimates correlated at r=0.91. Condition category: biomarker_context nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: The urinary assay mostly described free vitamin, not the cell’s activated CoA pool. organism: Homo sapiens tissue_or_cell_type: Fasting blood, 24-hour urine and seven-day diet records experimental_model: Observational study of 91 adults aged at least 65, including institutionalized and community participants limitations: Assay-specific findings; urinary free pantothenate is distinct from intracellular CoA and its acyl derivatives. exposure: Microbiological and radioimmunoassay analyses of free and derivative pantothenate fractions. cross_nutrient: false evidence_location: Primary indexed abstract. [b5-clin-tarr1981] Pantothenic acid nutritional status in the elderly--institutionalized and noninstitutionalized. (1981). https://pubmed.ncbi.nlm.nih.gov/7025609/ DOI: 10.1093/ajcn/34.9.1736
    Complete structured claim and evidence

What acts on it

  1. In 63 adolescents, recorded pantothenate intake correlated with urinary excretion (P<0.001); erythrocyte pantothenate also correlated with intake and urinary excretion.

    Pantothenate (vitamin B5) → Urinary pantothenate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary indexed abstract.
    experimental_model
    Observational study of 63 healthy adolescents
    exposure
    Four-day diet records; pantothenate measured by radioimmunoassay.
    limitations
    Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Urine and red-cell measurements tracked intake in this group.
    primary_references
    [b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931
    tissue_or_cell_type
    Diet records, urine, whole blood and erythrocytes
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1285–1297

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Observational study of 63 healthy adolescents · source_derived_draft · unverified_draft

    ### b5-clin-adolescent-urine-correlation In 63 adolescents, recorded pantothenate intake correlated with urinary excretion (P<0.001); erythrocyte pantothenate also correlated with intake and urinary excretion. Condition category: biomarker_context nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Urine and red-cell measurements tracked intake in this group. organism: Homo sapiens tissue_or_cell_type: Diet records, urine, whole blood and erythrocytes experimental_model: Observational study of 63 healthy adolescents limitations: Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance. exposure: Four-day diet records; pantothenate measured by radioimmunoassay. cross_nutrient: false evidence_location: Primary indexed abstract. [b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931
    Complete structured claim and evidence

  2. Urinary pantothenic acid approached zero after the eleventh week of the deficient diet in the 1958 experiment.

    Pantothenate (vitamin B5) → Urinary pantothenate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary PDF pp.1643–1654; design, results and discussion.
    experimental_model
    Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls
    exposure
    Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium.
    limitations
    Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Urinary B5 fell substantially during sustained dietary depletion.
    primary_references
    [b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756
    tissue_or_cell_type
    Whole-person symptoms, serum and urine
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1159–1171

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls · source_derived_draft · unverified_draft

    ### b5-clin-diet-urine Urinary pantothenic acid approached zero after the eleventh week of the deficient diet in the 1958 experiment. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Urinary B5 fell substantially during sustained dietary depletion. organism: Homo sapiens tissue_or_cell_type: Whole-person symptoms, serum and urine experimental_model: Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls limitations: Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold. exposure: Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium. cross_nutrient: false evidence_location: Primary PDF pp.1643–1654; design, results and discussion. [b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756
    Complete structured claim and evidence

  3. On the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg.

    Calcium pantothenate → Urinary pantothenate excretion source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The paper called the unexcreted fractions 63% and 48% retained on day one. These calculations do not directly measure absorption, tissue storage or CoA synthesis.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1257–1269

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-loading-urinary-recovery On the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The paper called the unexcreted fractions 63% and 48% retained on day one. These calculations do not directly measure absorption, tissue storage or CoA synthesis. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

  4. After 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation.

    Pantothenate (vitamin B5) → Urinary pantothenate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The authors reported no defined clinical deficiency syndrome over nine weeks, although listlessness and fatigue were noted near the end.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Urinary excretion responded strongly to whether B5 was supplied.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1229–1241

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-urine-intake-response After 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Urinary excretion responded strongly to whether B5 was supplied. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The authors reported no defined clinical deficiency syndrome over nine weeks, although listlessness and fatigue were noted near the end. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Whole-blood pantothenate decreased in the unsupplemented group and remained broadly stable in the supplemented group, but separated intake groups less readily than urinary excretion.

    Pantothenate (vitamin B5) → Blood pantothenate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Blood and urine measurements did not respond identically to dietary depletion.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1243–1255

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-blood-intake-response Whole-blood pantothenate decreased in the unsupplemented group and remained broadly stable in the supplemented group, but separated intake groups less readily than urinary excretion. Condition category: biomarker_context nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood and urine measurements did not respond identically to dietary depletion. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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