{"id":"ccb782cc-23fe-5d5e-8992-e23b21e3a145","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-urinary-species","predicate":"contains-measured","statement":"In the elderly cohort, free pantothenic acid was detected in urine, whereas the measured phosphoderivative fraction was not; microbiological and radioimmunoassay estimates correlated at r=0.91.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b34a295f-d6fb-5077-9cee-8989081d10f3","mechanism_event_label":"The urinary assay mostly described free vitamin, not the cell’s activated CoA pool.","subject":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"object":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b34a295f-d6fb-5077-9cee-8989081d10f3","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-urinary-species-event","event_type":"observed_intervention","label":"The urinary assay mostly described free vitamin, not the cell’s activated CoA pool.","description":"In the elderly cohort, free pantothenic acid was detected in urine, whereas the measured phosphoderivative fraction was not; microbiological and radioimmunoassay estimates correlated at r=0.91.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Observational study of 91 adults aged at least 65, including institutionalized and community participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Microbiological and radioimmunoassay analyses of free and derivative pantothenate fractions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay-specific findings; urinary free pantothenate is distinct from intracellular CoA and its acyl derivatives.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The urinary assay mostly described free vitamin, not the cell’s activated CoA pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-tarr1981] Pantothenic acid nutritional status in the elderly--institutionalized and noninstitutionalized. (1981). https://pubmed.ncbi.nlm.nih.gov/7025609/ DOI: 10.1093/ajcn/34.9.1736","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fasting blood, 24-hour urine and seven-day diet records","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b44a474c-39f8-5e9f-888e-0b24474846c5","evidence_kind":"source_excerpt","locator":"Lines 1313-1325","start_line":1313,"end_line":1325,"excerpt":"### b5-clin-urinary-species\nIn the elderly cohort, free pantothenic acid was detected in urine, whereas the measured phosphoderivative fraction was not; microbiological and radioimmunoassay estimates correlated at r=0.91.\nCondition category: biomarker_context\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The urinary assay mostly described free vitamin, not the cell’s activated CoA pool.\norganism: Homo sapiens\ntissue_or_cell_type: Fasting blood, 24-hour urine and seven-day diet records\nexperimental_model: Observational study of 91 adults aged at least 65, including institutionalized and community participants\nlimitations: Assay-specific findings; urinary free pantothenate is distinct from intracellular CoA and its acyl derivatives.\nexposure: Microbiological and radioimmunoassay analyses of free and derivative pantothenate fractions.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-tarr1981] Pantothenic acid nutritional status in the elderly--institutionalized and noninstitutionalized. 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