{"id":"2b2b63c4-d62f-5f48-9335-d3f123e56918","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-urine-intake-response","predicate":"deprivation-reduces","statement":"After 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f6b1d95f-defe-5f80-a3de-a00fc595b468","mechanism_event_label":"Urinary excretion responded strongly to whether B5 was supplied.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f6b1d95f-defe-5f80-a3de-a00fc595b468","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-urine-intake-response-event","event_type":"observed_intervention","label":"Urinary excretion responded strongly to whether B5 was supplied.","description":"After 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"60ba4878-8451-505d-a53f-c04b375c6a39","slug":"calcium-pantothenate","display_name":"Calcium pantothenate","entity_type_key":"small_molecule"},"role":"oral supplement formulation in comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The authors reported no defined clinical deficiency syndrome over nine weeks, although listlessness and fatigue were noted near the end.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Urinary excretion responded strongly to whether B5 was supplied.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine and whole blood; nitrogen balance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a45bae0c-2e89-5e42-b012-ff1cc4907d17","evidence_kind":"source_excerpt","locator":"Lines 1229-1241","start_line":1229,"end_line":1241,"excerpt":"### b5-clin-urine-intake-response\nAfter 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation.\nCondition category: nutrient_deficiency\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Urinary excretion responded strongly to whether B5 was supplied.\norganism: Homo sapiens\ntissue_or_cell_type: Urine and whole blood; nitrogen balance\nexperimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented\nlimitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The authors reported no defined clinical deficiency syndrome over nine weeks, although listlessness and fatigue were noted near the end.\nexposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.\ncross_nutrient: false\nevidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.\n[b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","model_system":"Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}