{"id":"48176b1e-db04-5eb3-9473-fa59ec3ad55e","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-loading-urinary-recovery","predicate":"loading-increases","statement":"On the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8c18dd82-31f5-5cb4-b7cc-e882a8726e83","mechanism_event_label":"Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week.","subject":{"id":"60ba4878-8451-505d-a53f-c04b375c6a39","slug":"calcium-pantothenate","display_name":"Calcium pantothenate","entity_type_key":"small_molecule"},"object":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8c18dd82-31f5-5cb4-b7cc-e882a8726e83","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-loading-urinary-recovery-event","event_type":"observed_intervention","label":"Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week.","description":"On the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"vitamin quantified in urine","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"60ba4878-8451-505d-a53f-c04b375c6a39","slug":"calcium-pantothenate","display_name":"Calcium pantothenate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The paper called the unexcreted fractions 63% and 48% retained on day one. These calculations do not directly measure absorption, tissue storage or CoA synthesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine and whole blood; nitrogen balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3ee943b1-bb27-55e9-b489-c8ffc2e7777e","evidence_kind":"source_excerpt","locator":"Lines 1257-1269","start_line":1257,"end_line":1269,"excerpt":"### b5-clin-loading-urinary-recovery\nOn the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week.\norganism: Homo sapiens\ntissue_or_cell_type: Urine and whole blood; nitrogen balance\nexperimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented\nlimitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The paper called the unexcreted fractions 63% and 48% retained on day one. These calculations do not directly measure absorption, tissue storage or CoA synthesis.\nexposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.\ncross_nutrient: false\nevidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.\n[b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","model_system":"Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}