Component

Blood pantothenate concentration

Blood pantothenate concentration. Experimental scope belongs to the associated record.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Although 49% of female and 15% of male adolescents recorded intakes below 4 mg/day, group-average blood concentrations were within the ranges reported for comparison populations.

    Pantothenate (vitamin B5) → Blood pantothenate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary indexed abstract.
    experimental_model
    Observational study of 63 healthy adolescents
    exposure
    Four-day diet records; pantothenate measured by radioimmunoassay.
    limitations
    Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance. Below 4 mg/day was a historical descriptive cutoff, not a validated individual deficiency threshold.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    A low short diet record did not reliably identify a low group-average blood value.
    primary_references
    [b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931
    tissue_or_cell_type
    Diet records, urine, whole blood and erythrocytes
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1299–1311

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Observational study of 63 healthy adolescents · source_derived_draft · unverified_draft

    ### b5-clin-adolescent-intake-blood-discordance Although 49% of female and 15% of male adolescents recorded intakes below 4 mg/day, group-average blood concentrations were within the ranges reported for comparison populations. Condition category: biomarker_context nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low short diet record did not reliably identify a low group-average blood value. organism: Homo sapiens tissue_or_cell_type: Diet records, urine, whole blood and erythrocytes experimental_model: Observational study of 63 healthy adolescents limitations: Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance. Below 4 mg/day was a historical descriptive cutoff, not a validated individual deficiency threshold. exposure: Four-day diet records; pantothenate measured by radioimmunoassay. cross_nutrient: false evidence_location: Primary indexed abstract. [b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931
    Complete structured claim and evidence

  2. Whole-blood pantothenate decreased in the unsupplemented group and remained broadly stable in the supplemented group, but separated intake groups less readily than urinary excretion.

    Pantothenate (vitamin B5) → Blood pantothenate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Blood and urine measurements did not respond identically to dietary depletion.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1243–1255

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-blood-intake-response Whole-blood pantothenate decreased in the unsupplemented group and remained broadly stable in the supplemented group, but separated intake groups less readily than urinary excretion. Condition category: biomarker_context nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood and urine measurements did not respond identically to dietary depletion. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

  3. Pantothenate after oral pantethine peaked at about 2.5 hours and fitted a two-compartment model with an estimated elimination half-life of 28 hours in the reported cystinosis study.

    Pantethine → Blood pantothenate concentration source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    evidence_location
    Primary indexed abstract.
    experimental_model
    Pharmacokinetic/metabolic study in four children with nephropathic cystinosis
    exposure
    Historical oral D-pantethine exposures 70–1000 mg/kg/day.
    limitations
    Very high drug-like exposures in a rare disease; not nutritional dosing, ordinary healthy-person pharmacokinetics or proof of the mechanism behind lipid-trial effects. Rat intestinal-enzyme kinetic data in the same paper are not assigned to humans. Model-specific estimate at high exposures in four children; not a normal dietary half-life.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Vitamin exposure persisted after the parent derivative was administered.
    primary_references
    [b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152
    tissue_or_cell_type
    Plasma after oral D-pantethine

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1481–1493

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pharmacokinetic/metabolic study in four children with nephropathic cystinosis · source_derived_draft · unverified_draft

    ### b5-clin-pantethine-pantothenate-kinetics Pantothenate after oral pantethine peaked at about 2.5 hours and fitted a two-compartment model with an estimated elimination half-life of 28 hours in the reported cystinosis study. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Vitamin exposure persisted after the parent derivative was administered. organism: Homo sapiens tissue_or_cell_type: Plasma after oral D-pantethine experimental_model: Pharmacokinetic/metabolic study in four children with nephropathic cystinosis limitations: Very high drug-like exposures in a rare disease; not nutritional dosing, ordinary healthy-person pharmacokinetics or proof of the mechanism behind lipid-trial effects. Rat intestinal-enzyme kinetic data in the same paper are not assigned to humans. Model-specific estimate at high exposures in four children; not a normal dietary half-life. exposure: Historical oral D-pantethine exposures 70–1000 mg/kg/day. cross_nutrient: false evidence_location: Primary indexed abstract. [b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards