{"id":"ef5747db-b979-5e7c-92c3-85340fe19966","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-adolescent-intake-blood-discordance","predicate":"low-recorded-intake-does-not-uniformly-lower","statement":"Although 49% of female and 15% of male adolescents recorded intakes below 4 mg/day, group-average blood concentrations were within the ranges reported for comparison populations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"20e486e5-fc6b-5198-addf-e9b21ad30872","mechanism_event_label":"A low short diet record did not reliably identify a low group-average blood value.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"0f70446f-3a13-5662-b780-f9361125d26f","slug":"blood-pantothenate-concentration","display_name":"Blood pantothenate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"20e486e5-fc6b-5198-addf-e9b21ad30872","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-adolescent-intake-blood-discordance-event","event_type":"observed_intervention","label":"A low short diet record did not reliably identify a low group-average blood value.","description":"Although 49% of female and 15% of male adolescents recorded intakes below 4 mg/day, group-average blood concentrations were within the ranges reported for comparison populations.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f70446f-3a13-5662-b780-f9361125d26f","slug":"blood-pantothenate-concentration","display_name":"Blood pantothenate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Observational study of 63 healthy adolescents","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Four-day diet records; pantothenate measured by radioimmunoassay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance. Below 4 mg/day was a historical descriptive cutoff, not a validated individual deficiency threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low short diet record did not reliably identify a low group-average blood value.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Diet records, urine, whole blood and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1babbff7-ea64-5677-881e-8e7433d98c03","evidence_kind":"source_excerpt","locator":"Lines 1299-1311","start_line":1299,"end_line":1311,"excerpt":"### b5-clin-adolescent-intake-blood-discordance\nAlthough 49% of female and 15% of male adolescents recorded intakes below 4 mg/day, group-average blood concentrations were within the ranges reported for comparison populations.\nCondition category: biomarker_context\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low short diet record did not reliably identify a low group-average blood value.\norganism: Homo sapiens\ntissue_or_cell_type: Diet records, urine, whole blood and erythrocytes\nexperimental_model: Observational study of 63 healthy adolescents\nlimitations: Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance. Below 4 mg/day was a historical descriptive cutoff, not a validated individual deficiency threshold.\nexposure: Four-day diet records; pantothenate measured by radioimmunoassay.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931","model_system":"Observational study of 63 healthy adolescents","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}