{"id":"8498dd28-ed1b-5a4b-93df-6a2695a8a078","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-pantothenate-kinetics","predicate":"administration-elevates","statement":"Pantothenate after oral pantethine peaked at about 2.5 hours and fitted a two-compartment model with an estimated elimination half-life of 28 hours in the reported cystinosis study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"110c6ee0-1dc9-5cf8-9551-db79940b15ca","mechanism_event_label":"Vitamin exposure persisted after the parent derivative was administered.","subject":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"object":{"id":"0f70446f-3a13-5662-b780-f9361125d26f","slug":"blood-pantothenate-concentration","display_name":"Blood pantothenate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"110c6ee0-1dc9-5cf8-9551-db79940b15ca","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-pantothenate-kinetics-event","event_type":"observed_intervention","label":"Vitamin exposure persisted after the parent derivative was administered.","description":"Pantothenate after oral pantethine peaked at about 2.5 hours and fitted a two-compartment model with an estimated elimination half-life of 28 hours in the reported cystinosis study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"measured vitamin product","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0f70446f-3a13-5662-b780-f9361125d26f","slug":"blood-pantothenate-concentration","display_name":"Blood pantothenate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pharmacokinetic/metabolic study in four children with nephropathic cystinosis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Historical oral D-pantethine exposures 70–1000 mg/kg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very high drug-like exposures in a rare disease; not nutritional dosing, ordinary healthy-person pharmacokinetics or proof of the mechanism behind lipid-trial effects. Rat intestinal-enzyme kinetic data in the same paper are not assigned to humans. Model-specific estimate at high exposures in four children; not a normal dietary half-life.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin exposure persisted after the parent derivative was administered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma after oral D-pantethine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"81aa5578-9881-5dca-a6bf-abaf6d8196c8","evidence_kind":"source_excerpt","locator":"Lines 1481-1493","start_line":1481,"end_line":1493,"excerpt":"### b5-clin-pantethine-pantothenate-kinetics\nPantothenate after oral pantethine peaked at about 2.5 hours and fitted a two-compartment model with an estimated elimination half-life of 28 hours in the reported cystinosis study.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin exposure persisted after the parent derivative was administered.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma after oral D-pantethine\nexperimental_model: Pharmacokinetic/metabolic study in four children with nephropathic cystinosis\nlimitations: Very high drug-like exposures in a rare disease; not nutritional dosing, ordinary healthy-person pharmacokinetics or proof of the mechanism behind lipid-trial effects. Rat intestinal-enzyme kinetic data in the same paper are not assigned to humans. Model-specific estimate at high exposures in four children; not a normal dietary half-life.\nexposure: Historical oral D-pantethine exposures 70–1000 mg/kg/day.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152","model_system":"Pharmacokinetic/metabolic study in four children with nephropathic cystinosis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-wittwer1985] Metabolism of pantethine in cystinosis. (1985). https://pubmed.ncbi.nlm.nih.gov/4056044/ DOI: 10.1172/jci112152","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}