Component

Calcium pantothenate

Calcium salt formulation of pantothenate; stated doses refer to vitamin content when the primary study says so.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. On the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg.

    Calcium pantothenate → Urinary pantothenate excretion source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The paper called the unexcreted fractions 63% and 48% retained on day one. These calculations do not directly measure absorption, tissue storage or CoA synthesis.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1257–1269

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-loading-urinary-recovery On the first 100 mg B5 loading day, prior unsupplemented subjects excreted about 37 mg and supplemented subjects about 52 mg in urine; by day seven the means were about 59 and 62 mg. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Prior intake changed urinary recovery of a loading dose, and the groups became more similar over a week. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The paper called the unexcreted fractions 63% and 48% retained on day one. These calculations do not directly measure absorption, tissue storage or CoA synthesis. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

  2. Mean nitrogen balance was numerically higher with 10 mg/day B5 than without supplementation, but the between-group difference was not statistically significant.

    Calcium pantothenate → Whole-body nitrogen balance source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. A numerical trend does not establish enhanced protein synthesis or an amino-acid repletion gate.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    This study did not demonstrate a significant improvement in nitrogen balance.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1271–1283

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-nitrogen-not-significant Mean nitrogen balance was numerically higher with 10 mg/day B5 than without supplementation, but the between-group difference was not statistically significant. Condition category: normal nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: This study did not demonstrate a significant improvement in nitrogen balance. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. A numerical trend does not establish enhanced protein synthesis or an amino-acid repletion gate. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. After 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation.

    Pantothenate (vitamin B5) → Urinary pantothenate excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    false
    evidence_location
    Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.
    experimental_model
    Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented
    exposure
    Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.
    limitations
    Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The authors reported no defined clinical deficiency syndrome over nine weeks, although listlessness and fatigue were noted near the end.
    nutrient_topic
    Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. · Pantothenate (vitamin B5)
    organism
    Homo sapiens
    plain_language
    Urinary excretion responded strongly to whether B5 was supplied.
    primary_references
    [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    tissue_or_cell_type
    Urine and whole blood; nitrogen balance
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17) · lines 1229–1241

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented · source_derived_draft · unverified_draft

    ### b5-clin-urine-intake-response After 63 days, mean urinary pantothenate fell from 3.05 to 0.79 mg/day in the unsupplemented men; it rose from 3.95 to 5.84 mg/day with 10 mg/day supplementation. Condition category: nutrient_deficiency nutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Urinary excretion responded strongly to whether B5 was supplied. organism: Homo sapiens tissue_or_cell_type: Urine and whole blood; nitrogen balance experimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented limitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. The authors reported no defined clinical deficiency syndrome over nine weeks, although listlessness and fatigue were noted near the end. exposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days. cross_nutrient: false evidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345. [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards