{"id":"98bfaae9-c95f-5f8e-8aa7-275a7c2d4df6","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-nitrogen-not-significant","predicate":"does-not-significantly-change","statement":"Mean nitrogen balance was numerically higher with 10 mg/day B5 than without supplementation, but the between-group difference was not statistically significant.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ed5b83f9-a4f4-5b35-8785-33a2e16b47ae","mechanism_event_label":"This study did not demonstrate a significant improvement in nitrogen balance.","subject":{"id":"60ba4878-8451-505d-a53f-c04b375c6a39","slug":"calcium-pantothenate","display_name":"Calcium pantothenate","entity_type_key":"small_molecule"},"object":{"id":"cc5aa58f-fb60-5cb3-9557-c5e412e33d4f","slug":"whole-body-nitrogen-balance","display_name":"Whole-body nitrogen balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ed5b83f9-a4f4-5b35-8785-33a2e16b47ae","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-nitrogen-not-significant-event","event_type":"observed_intervention","label":"This study did not demonstrate a significant improvement in nitrogen balance.","description":"Mean nitrogen balance was numerically higher with 10 mg/day B5 than without supplementation, but the between-group difference was not statistically significant.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"60ba4878-8451-505d-a53f-c04b375c6a39","slug":"calcium-pantothenate","display_name":"Calcium pantothenate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cc5aa58f-fb60-5cb3-9557-c5e412e33d4f","slug":"whole-body-nitrogen-balance","display_name":"Whole-body nitrogen balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. A numerical trend does not establish enhanced protein synthesis or an amino-acid repletion gate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This study did not demonstrate a significant improvement in nitrogen balance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine and whole blood; nitrogen balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c53f9299-c456-51b9-8cfb-db589892ea43","evidence_kind":"source_excerpt","locator":"Lines 1271-1283","start_line":1271,"end_line":1283,"excerpt":"### b5-clin-nitrogen-not-significant\nMean nitrogen balance was numerically higher with 10 mg/day B5 than without supplementation, but the between-group difference was not statistically significant.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This study did not demonstrate a significant improvement in nitrogen balance.\norganism: Homo sapiens\ntissue_or_cell_type: Urine and whole blood; nitrogen balance\nexperimental_model: Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented\nlimitations: Table 1 and the abstract distinguish unsupplemented and supplemented groups; one Methods sentence incorrectly says all received 10 mg. The table was visually checked. Historical assay and small cohort; the reported retention calculation is not direct measurement of intestinal absorption or tissue CoA. A numerical trend does not establish enhanced protein synthesis or an amino-acid repletion gate.\nexposure: Nine-week/63-day experimental diet essentially free of B5 versus 10 mg/day B5 as calcium pantothenate; both groups then received 100 mg/day for seven days.\ncross_nutrient: false\nevidence_location: Primary PDF Table 1 visually checked; Tables 3–4 and Results pp.341–345.\n[b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","model_system":"Controlled 84-day feeding experiment in ten adult male inmates aged 27–33; six unsupplemented and four supplemented","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-fry1976] Metabolic response to a pantothenic acid deficient diet in humans. (1976). https://pubmed.ncbi.nlm.nih.gov/1011047/ DOI: 10.3177/jnsv.22.339","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}