{"id":"ecb4301e-0d87-5e72-a36e-9f6d6e916299","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-adolescent-urine-correlation","predicate":"dietary-intake-correlates-with","statement":"In 63 adolescents, recorded pantothenate intake correlated with urinary excretion (P<0.001); erythrocyte pantothenate also correlated with intake and urinary excretion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5e3698c0-f985-54a7-bba2-35b97986571a","mechanism_event_label":"Urine and red-cell measurements tracked intake in this group.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5e3698c0-f985-54a7-bba2-35b97986571a","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-adolescent-urine-correlation-event","event_type":"observed_intervention","label":"Urine and red-cell measurements tracked intake in this group.","description":"In 63 adolescents, recorded pantothenate intake correlated with urinary excretion (P<0.001); erythrocyte pantothenate also correlated with intake and urinary excretion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"88cab32f-616d-5ac3-bd75-e3834c4bf313","slug":"erythrocyte-pantothenate-concentration","display_name":"Erythrocyte pantothenate concentration","entity_type_key":"cellular_process"},"role":"additional measured pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca673e1d-0c2b-50ca-9708-703f2efb78e5","slug":"urinary-pantothenate-excretion","display_name":"Urinary pantothenate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Observational study of 63 healthy adolescents","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Four-day diet records; pantothenate measured by radioimmunoassay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Urine and red-cell measurements tracked intake in this group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Diet records, urine, whole blood and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"af86fd5d-702a-5bce-9893-2f3342215a08","evidence_kind":"source_excerpt","locator":"Lines 1285-1297","start_line":1285,"end_line":1297,"excerpt":"### b5-clin-adolescent-urine-correlation\nIn 63 adolescents, recorded pantothenate intake correlated with urinary excretion (P<0.001); erythrocyte pantothenate also correlated with intake and urinary excretion.\nCondition category: biomarker_context\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Urine and red-cell measurements tracked intake in this group.\norganism: Homo sapiens\ntissue_or_cell_type: Diet records, urine, whole blood and erythrocytes\nexperimental_model: Observational study of 63 healthy adolescents\nlimitations: Correlations and comparisons with other populations do not establish cellular adequacy, an individual requirement or a diagnostic threshold. Historical recommended-intake discussion is not used as current guidance.\nexposure: Four-day diet records; pantothenate measured by radioimmunoassay.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-eissenstat1986] Pantothenic acid status of adolescents. (1986). https://pubmed.ncbi.nlm.nih.gov/3788840/ DOI: 10.1093/ajcn/44.6.931","model_system":"Observational study of 63 healthy adolescents","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-eissenstat1986] Pantothenic acid status of adolescents. 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