Component

Urinary manganese excretion

Urinary manganese excretion. Experimental scope belongs to each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Chelation increased urinary manganese and reduced blood manganese in the followed SLC30A10 patient.

    Calcium disodium edetate → Urinary manganese excretion source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    cross_nutrient
    Whole-blood manganese concentration (reduced_endpoint); Manganese (removed_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.txt", "locator": "Clinical description; initial calcium disodium edetate treatment", "file_sha256": "5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6", "start_char": 8926, "end_char": 9841, "text_sha256": "0bc6daa528aab341fb9d91dc543811ba24f7f8e904f084c085bafc1d4093113e", "text_characters": 915}
    experimental_model
    Ten-year longitudinal report of one SLC30A10 patient
    exposure
    Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.
    limitations
    Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The treatment moved more manganese into urine.
    primary_references
    [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
    tissue_or_cell_type
    Urine, blood, brain MRI and motor function
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1272–1284

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ten-year longitudinal report of one SLC30A10 patient · source_derived_draft · unverified_draft

    ### mn-clin-chelation-manganese-removal Chelation increased urinary manganese and reduced blood manganese in the followed SLC30A10 patient. Condition category: machinery_impairment nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The treatment moved more manganese into urine. organism: Homo sapiens tissue_or_cell_type: Urine, blood, brain MRI and motor function experimental_model: Ten-year longitudinal report of one SLC30A10 patient limitations: Repeated observations in one previously described patient. Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement. exposure: Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate. cross_nutrient: Whole-blood manganese concentration (reduced_endpoint); Manganese (removed_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/stamelou2012.txt", "locator": "Clinical description; initial calcium disodium edetate treatment", "file_sha256": "5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6", "start_char": 8926, "end_char": 9841, "text_sha256": "0bc6daa528aab341fb9d91dc543811ba24f7f8e904f084c085bafc1d4093113e", "text_characters": 915} [mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. (2012). https://pubmed.ncbi.nlm.nih.gov/22926781/ DOI: 10.1002/mds.25138
    Complete structured claim and evidence

  2. Manganese supplementation did not change measured urinary manganese excretion.

    Manganese → Urinary manganese excretion source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Manganese handling and the measured downstream function.
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davis1992a.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "start_char": 0, "end_char": 956, "text_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "text_characters": 956}
    experimental_model
    124-day supplementation study in 47 women
    exposure
    Placebo, 60 mg iron/day, 15 mg manganese/day or both.
    limitations
    Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Urinary manganese did not track the serum response in this study.
    primary_references
    [mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747
    tissue_or_cell_type
    Lymphocytes, serum and urine

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1132–1144

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 124-day supplementation study in 47 women · source_derived_draft · unverified_draft

    ### mn-clin-supplement-urine Manganese supplementation did not change measured urinary manganese excretion. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Urinary manganese did not track the serum response in this study. organism: Homo sapiens tissue_or_cell_type: Lymphocytes, serum and urine experimental_model: 124-day supplementation study in 47 women limitations: Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold. exposure: Placebo, 60 mg iron/day, 15 mg manganese/day or both. cross_nutrient: Manganese handling and the measured downstream function. evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davis1992a.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "start_char": 0, "end_char": 956, "text_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "text_characters": 956} [mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Higher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern.

    Nonheme dietary iron → Lymphocyte manganese superoxide dismutase activity source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Heme iron (comparison_form); Serum manganese concentration (associated_endpoint); Urinary manganese excretion (associated_endpoint); Manganese (affected_nutrient); Iron (associated_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davis1992b.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "start_char": 0, "end_char": 1172, "text_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "text_characters": 1172}
    experimental_model
    Dietary association analysis in 47 women consuming usual diets
    exposure
    Comparisons of manganese, heme-iron and nonheme-iron intake.
    limitations
    Observational food-pattern associations cannot isolate a transporter or iron itself from correlated dietary factors. This may analyze participants related to the companion supplementation report; papers are not independent trials.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Food form and the rest of the diet changed the observed iron–manganese relationship.
    primary_references
    [mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926
    tissue_or_cell_type
    Serum, urine and lymphocyte enzymes

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1160–1172

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary association analysis in 47 women consuming usual diets · source_derived_draft · unverified_draft

    ### mn-clin-nonheme-association Higher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Food form and the rest of the diet changed the observed iron–manganese relationship. organism: Homo sapiens tissue_or_cell_type: Serum, urine and lymphocyte enzymes experimental_model: Dietary association analysis in 47 women consuming usual diets limitations: Observational food-pattern associations cannot isolate a transporter or iron itself from correlated dietary factors. This may analyze participants related to the companion supplementation report; papers are not independent trials. exposure: Comparisons of manganese, heme-iron and nonheme-iron intake. cross_nutrient: Heme iron (comparison_form); Serum manganese concentration (associated_endpoint); Urinary manganese excretion (associated_endpoint); Manganese (affected_nutrient); Iron (associated_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davis1992b.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "start_char": 0, "end_char": 1172, "text_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "text_characters": 1172} [mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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