{"id":"717f648a-3eb1-55af-8890-4a078a029f40","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-nonheme-association","predicate":"was_inversely_associated_with","statement":"Higher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b184e9be-636a-5e79-8533-a6cebb9f407c","mechanism_event_label":"Food form and the rest of the diet changed the observed iron–manganese relationship.","subject":{"id":"6004925e-00be-56b0-a3f1-28d0353fd7c6","slug":"nonheme-dietary-iron","display_name":"Nonheme dietary iron","entity_type_key":"chemical_species"},"object":{"id":"c8d4a4dc-c415-5696-8f3f-64b8a9925ced","slug":"lymphocyte-mnsod-activity","display_name":"Lymphocyte manganese superoxide dismutase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b184e9be-636a-5e79-8533-a6cebb9f407c","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-nonheme-association-event","event_type":"observed_intervention","label":"Food form and the rest of the diet changed the observed iron–manganese relationship.","description":"Higher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a70b82b8-8b62-5a2e-abb2-0cdc8c747a3b","slug":"heme-iron","display_name":"Heme iron","entity_type_key":"chemical_species"},"role":"comparison_form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"31b16b9c-8864-50a7-b496-70c042783087","slug":"serum-manganese-concentration","display_name":"Serum manganese concentration","entity_type_key":"cellular_process"},"role":"associated_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce5f46b8-312b-573b-8150-9a5ae46cefbf","slug":"urinary-manganese-excretion","display_name":"Urinary manganese excretion","entity_type_key":"cellular_process"},"role":"associated_endpoint","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"associated_nutrient","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"6004925e-00be-56b0-a3f1-28d0353fd7c6","slug":"nonheme-dietary-iron","display_name":"Nonheme dietary iron","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"c8d4a4dc-c415-5696-8f3f-64b8a9925ced","slug":"lymphocyte-mnsod-activity","display_name":"Lymphocyte manganese superoxide dismutase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Heme iron (comparison_form); Serum manganese concentration (associated_endpoint); Urinary manganese excretion (associated_endpoint); Manganese (affected_nutrient); Iron (associated_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/davis1992b.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102\", \"start_char\": 0, \"end_char\": 1172, \"text_sha256\": \"8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102\", \"text_characters\": 1172}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary association analysis in 47 women consuming usual diets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Comparisons of manganese, heme-iron and nonheme-iron intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational food-pattern associations cannot isolate a transporter or iron itself from correlated dietary factors. This may analyze participants related to the companion supplementation report; papers are not independent trials.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Food form and the rest of the diet changed the observed iron–manganese relationship.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum, urine and lymphocyte enzymes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e96346d2-b704-516f-85c0-19a6a0235a07","evidence_kind":"source_excerpt","locator":"Lines 1160-1172","start_line":1160,"end_line":1172,"excerpt":"### mn-clin-nonheme-association\nHigher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Food form and the rest of the diet changed the observed iron–manganese relationship.\norganism: Homo sapiens\ntissue_or_cell_type: Serum, urine and lymphocyte enzymes\nexperimental_model: Dietary association analysis in 47 women consuming usual diets\nlimitations: Observational food-pattern associations cannot isolate a transporter or iron itself from correlated dietary factors. This may analyze participants related to the companion supplementation report; papers are not independent trials.\nexposure: Comparisons of manganese, heme-iron and nonheme-iron intake.\ncross_nutrient: Heme iron (comparison_form); Serum manganese concentration (associated_endpoint); Urinary manganese excretion (associated_endpoint); Manganese (affected_nutrient); Iron (associated_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/davis1992b.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102\", \"start_char\": 0, \"end_char\": 1172, \"text_sha256\": \"8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102\", \"text_characters\": 1172}\n[mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926","model_system":"Dietary association analysis in 47 women consuming usual diets","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"03224387-8a73-5b4f-906d-9f0be6625b7f","stable_key":"import-be889add-cec8-500b-be89-676431432a70","title":"Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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