Component

Lymphocyte manganese superoxide dismutase activity

Lymphocyte manganese superoxide dismutase activity. Experimental scope belongs to each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Higher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern.

    Nonheme dietary iron → Lymphocyte manganese superoxide dismutase activity source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Heme iron (comparison_form); Serum manganese concentration (associated_endpoint); Urinary manganese excretion (associated_endpoint); Manganese (affected_nutrient); Iron (associated_nutrient)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davis1992b.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "start_char": 0, "end_char": 1172, "text_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "text_characters": 1172}
    experimental_model
    Dietary association analysis in 47 women consuming usual diets
    exposure
    Comparisons of manganese, heme-iron and nonheme-iron intake.
    limitations
    Observational food-pattern associations cannot isolate a transporter or iron itself from correlated dietary factors. This may analyze participants related to the companion supplementation report; papers are not independent trials.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    Food form and the rest of the diet changed the observed iron–manganese relationship.
    primary_references
    [mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926
    tissue_or_cell_type
    Serum, urine and lymphocyte enzymes

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1160–1172

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary association analysis in 47 women consuming usual diets · source_derived_draft · unverified_draft

    ### mn-clin-nonheme-association Higher nonheme-iron intake was associated with lower serum and urinary manganese and lymphocyte MnSOD activity; heme-iron intake showed no consistent manganese pattern. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: Food form and the rest of the diet changed the observed iron–manganese relationship. organism: Homo sapiens tissue_or_cell_type: Serum, urine and lymphocyte enzymes experimental_model: Dietary association analysis in 47 women consuming usual diets limitations: Observational food-pattern associations cannot isolate a transporter or iron itself from correlated dietary factors. This may analyze participants related to the companion supplementation report; papers are not independent trials. exposure: Comparisons of manganese, heme-iron and nonheme-iron intake. cross_nutrient: Heme iron (comparison_form); Serum manganese concentration (associated_endpoint); Urinary manganese excretion (associated_endpoint); Manganese (affected_nutrient); Iron (associated_nutrient) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davis1992b.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "start_char": 0, "end_char": 1172, "text_sha256": "8542f3e0bd8f5903e6ce9e30fba2a6d7797a822ab1aeeab992659ba482533102", "text_characters": 1172} [mn-clin-davis1992b] Interactions among dietary manganese, heme iron, and nonheme iron in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1415012/ DOI: 10.1093/ajcn/56.5.926
    Complete structured claim and evidence

  2. Manganese supplementation increased lymphocyte MnSOD activity from baseline.

    Manganese → Lymphocyte manganese superoxide dismutase activity source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Mitochondrial superoxide dismutase / SOD2 (measured_enzyme); Iron (factorial_comparator)
    evidence_span
    {"source_cache": "artifacts/manganese-clinical-sources/davis1992a.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "start_char": 0, "end_char": 956, "text_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "text_characters": 956}
    experimental_model
    124-day supplementation study in 47 women
    exposure
    Placebo, 60 mg iron/day, 15 mg manganese/day or both.
    limitations
    Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold.
    nutrient_topic
    Manganese research collection; topical membership is not evidence of a direct dietary effect. · Manganese
    organism
    Homo sapiens
    plain_language
    The manganese enzyme responded in the sampled immune cells.
    primary_references
    [mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747
    tissue_or_cell_type
    Lymphocytes, serum and urine

    Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17) · lines 1104–1116

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 124-day supplementation study in 47 women · source_derived_draft · unverified_draft

    ### mn-clin-supplement-lymphocyte-sod Manganese supplementation increased lymphocyte MnSOD activity from baseline. Condition category: normal nutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect. plain_language: The manganese enzyme responded in the sampled immune cells. organism: Homo sapiens tissue_or_cell_type: Lymphocytes, serum and urine experimental_model: 124-day supplementation study in 47 women limitations: Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold. exposure: Placebo, 60 mg iron/day, 15 mg manganese/day or both. cross_nutrient: Mitochondrial superoxide dismutase / SOD2 (measured_enzyme); Iron (factorial_comparator) evidence_span: {"source_cache": "artifacts/manganese-clinical-sources/davis1992a.abstract.txt", "locator": "Indexed primary abstract", "file_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "start_char": 0, "end_char": 956, "text_sha256": "2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227", "text_characters": 956} [mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards