{"id":"82e52819-4509-58ab-82ee-79415625fc59","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-supplement-lymphocyte-sod","predicate":"increased","statement":"Manganese supplementation increased lymphocyte MnSOD activity from baseline.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e5e1f31f-002d-5535-b06a-3af2d1f23649","mechanism_event_label":"The manganese enzyme responded in the sampled immune cells.","subject":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"object":{"id":"c8d4a4dc-c415-5696-8f3f-64b8a9925ced","slug":"lymphocyte-mnsod-activity","display_name":"Lymphocyte manganese superoxide dismutase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e5e1f31f-002d-5535-b06a-3af2d1f23649","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-supplement-lymphocyte-sod-event","event_type":"observed_intervention","label":"The manganese enzyme responded in the sampled immune cells.","description":"Manganese supplementation increased lymphocyte MnSOD activity from baseline.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eda566c2-d338-54b2-a872-0dd39daffcdf","slug":"sod2","display_name":"Human mitochondrial manganese superoxide dismutase / SOD2","entity_type_key":"protein"},"role":"measured_enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"factorial_comparator","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c8d4a4dc-c415-5696-8f3f-64b8a9925ced","slug":"lymphocyte-mnsod-activity","display_name":"Lymphocyte manganese superoxide dismutase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Mitochondrial superoxide dismutase / SOD2 (measured_enzyme); Iron (factorial_comparator)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/davis1992a.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"start_char\": 0, \"end_char\": 956, \"text_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"text_characters\": 956}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"124-day supplementation study in 47 women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Placebo, 60 mg iron/day, 15 mg manganese/day or both.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The manganese enzyme responded in the sampled immune cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Lymphocytes, serum and urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5c0aa521-be19-5f54-b8cd-1ec6a182c723","evidence_kind":"source_excerpt","locator":"Lines 1104-1116","start_line":1104,"end_line":1116,"excerpt":"### mn-clin-supplement-lymphocyte-sod\nManganese supplementation increased lymphocyte MnSOD activity from baseline.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The manganese enzyme responded in the sampled immune cells.\norganism: Homo sapiens\ntissue_or_cell_type: Lymphocytes, serum and urine\nexperimental_model: 124-day supplementation study in 47 women\nlimitations: Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold.\nexposure: Placebo, 60 mg iron/day, 15 mg manganese/day or both.\ncross_nutrient: Mitochondrial superoxide dismutase / SOD2 (measured_enzyme); Iron (factorial_comparator)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/davis1992a.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"start_char\": 0, \"end_char\": 956, \"text_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"text_characters\": 956}\n[mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747","model_system":"124-day supplementation study in 47 women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"03224387-8a73-5b4f-906d-9f0be6625b7f","stable_key":"import-be889add-cec8-500b-be89-676431432a70","title":"Manganese: enzyme cofactors, glycosylation, transport and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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