{"id":"8b0ac8df-690e-5626-a0e2-6fc41ead19b0","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-supplement-urine","predicate":"did_not_change","statement":"Manganese supplementation did not change measured urinary manganese excretion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"8d3b9ba8-4303-5afa-8722-09b30e932dee","mechanism_event_label":"Urinary manganese did not track the serum response in this study.","subject":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"object":{"id":"ce5f46b8-312b-573b-8150-9a5ae46cefbf","slug":"urinary-manganese-excretion","display_name":"Urinary manganese excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8d3b9ba8-4303-5afa-8722-09b30e932dee","stable_key":"be889add-cec8-500b-be89-676431432a70:mn-clin-supplement-urine-event","event_type":"observed_intervention","label":"Urinary manganese did not track the serum response in this study.","description":"Manganese supplementation did not change measured urinary manganese excretion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f0459455-8231-513b-8214-7ea5b3259b4b","slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ce5f46b8-312b-573b-8150-9a5ae46cefbf","slug":"urinary-manganese-excretion","display_name":"Urinary manganese excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Manganese handling and the measured downstream function.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/manganese-clinical-sources/davis1992a.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"start_char\": 0, \"end_char\": 956, \"text_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"text_characters\": 956}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"124-day supplementation study in 47 women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Placebo, 60 mg iron/day, 15 mg manganese/day or both.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Urinary manganese did not track the serum response in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. (1992). https://pubmed.ncbi.nlm.nih.gov/1550052/ DOI: 10.1093/ajcn/55.3.747","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Lymphocytes, serum and urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a13f0a9c-d7c3-53aa-b002-7c5a709b796c","evidence_kind":"source_excerpt","locator":"Lines 1132-1144","start_line":1132,"end_line":1144,"excerpt":"### mn-clin-supplement-urine\nManganese supplementation did not change measured urinary manganese excretion.\nCondition category: normal\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Urinary manganese did not track the serum response in this study.\norganism: Homo sapiens\ntissue_or_cell_type: Lymphocytes, serum and urine\nexperimental_model: 124-day supplementation study in 47 women\nlimitations: Historical experimental doses, not intake advice. Abstract reports manganese changes from baseline; biomarkers do not demonstrate improved health or establish a deficiency threshold.\nexposure: Placebo, 60 mg iron/day, 15 mg manganese/day or both.\ncross_nutrient: Manganese handling and the measured downstream function.\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/davis1992a.abstract.txt\", \"locator\": \"Indexed primary abstract\", \"file_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"start_char\": 0, \"end_char\": 956, \"text_sha256\": \"2fbf15cf32ba80f68c4f4efaa7fa50de76b90094438325cc6632b7d447e22227\", \"text_characters\": 956}\n[mn-clin-davis1992a] Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. 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