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Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Manganese research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"manganese","display_name":"Manganese","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The treatment moved more manganese into urine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. 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Combined treatment changes prevent attribution of later benefit to iron alone; disease-specific treatment is not routine nutrient replacement.\nexposure: Calcium disodium edetate chelation; subsequent increase in chelation frequency and addition of oral ferrous fumarate.\ncross_nutrient: Whole-blood manganese concentration (reduced_endpoint); Manganese (removed_nutrient)\nevidence_span: {\"source_cache\": \"artifacts/manganese-clinical-sources/stamelou2012.txt\", \"locator\": \"Clinical description; initial calcium disodium edetate treatment\", \"file_sha256\": \"5d86a26fe564508fb382d1c8df61f531bfbaf06b69e2078b0999e3a3129555f6\", \"start_char\": 8926, \"end_char\": 9841, \"text_sha256\": \"0bc6daa528aab341fb9d91dc543811ba24f7f8e904f084c085bafc1d4093113e\", \"text_characters\": 915}\n[mn-clin-stamelou2012] Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: a new treatable disorder. 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