Component

Serum ceruloplasmin concentration

Serum ceruloplasmin concentration; read each linked claim for the measured context and model.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In the sixteen-person longitudinal group, plasma copper and ceruloplasmin declined over follow-up, with a reported copper-deficiency incidence of 18.8%.

    Biochemically low copper status → Serum ceruloplasmin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/copper-research/21876546.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8", "start_char": 0, "end_char": 1842, "text_sha256": "29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8"}
    experimental_model
    Post-Roux-en-Y clinic cohort and longitudinal subset
    exposure
    136-person clinic cohort; separate longitudinal group of sixteen
    limitations
    Clinic selection and small longitudinal sample limit generalization; the study does not establish the sole molecular cause of every postoperative symptom.
    nutrient_topic
    Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
    organism
    Human
    plain_language
    Following the same people over time detected falling copper-related measures.
    primary_references
    [copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159
    tissue_or_cell_type
    Blood and clinical findings after gastric bypass
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1404–1415

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Post-Roux-en-Y clinic cohort and longitudinal subset · source_derived_draft · unverified_draft

    ### copper-bypass-cp-timecourse In the sixteen-person longitudinal group, plasma copper and ceruloplasmin declined over follow-up, with a reported copper-deficiency incidence of 18.8%. Condition category: nutrient_deficiency nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Following the same people over time detected falling copper-related measures. organism: Human tissue_or_cell_type: Blood and clinical findings after gastric bypass experimental_model: Post-Roux-en-Y clinic cohort and longitudinal subset limitations: Clinic selection and small longitudinal sample limit generalization; the study does not establish the sole molecular cause of every postoperative symptom. exposure: 136-person clinic cohort; separate longitudinal group of sixteen evidence_span: {"source_cache": "artifacts/copper-research/21876546.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8", "start_char": 0, "end_char": 1842, "text_sha256": "29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8"} [copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159
    Complete structured claim and evidence

  2. Serum ceruloplasmin was unchanged in both intervention groups despite lower erythrocyte Cu/Zn-superoxide dismutase activity; serum zinc rose in both groups.

    Zinc gluconate → Serum ceruloplasmin concentration source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Copper (affected_nutrient); Serum zinc concentration (increased_marker); Erythrocyte copper/zinc superoxide dismutase activity (decreased_marker)
    evidence_location
    Indexed primary abstract.
    evidence_span
    {"source_cache": "artifacts/zinc-clinical-sources/yadrick1989.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443", "utf8_bytes": 969}
    experimental_model
    Ten-week zinc or zinc-plus-iron intervention in adult women
    exposure
    50 mg elemental zinc/day as gluconate, with or without 50 mg iron/day as ferrous sulfate monohydrate.
    limitations
    Reported comparisons are within-group pretreatment versus 10 weeks, not placebo-adjusted effects. ESOD is a functional biomarker, not a diagnosis of symptomatic copper deficiency.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Homo sapiens
    plain_language
    A rising zinc blood level and unchanged ceruloplasmin did not capture every functional change.
    primary_references
    [zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145
    tissue_or_cell_type
    Blood and erythrocytes

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1211–1224

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ten-week zinc or zinc-plus-iron intervention in adult women · source_derived_draft · unverified_draft

    ### zn-clin-ceruloplasmin-null Serum ceruloplasmin was unchanged in both intervention groups despite lower erythrocyte Cu/Zn-superoxide dismutase activity; serum zinc rose in both groups. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A rising zinc blood level and unchanged ceruloplasmin did not capture every functional change. organism: Homo sapiens tissue_or_cell_type: Blood and erythrocytes experimental_model: Ten-week zinc or zinc-plus-iron intervention in adult women limitations: Reported comparisons are within-group pretreatment versus 10 weeks, not placebo-adjusted effects. ESOD is a functional biomarker, not a diagnosis of symptomatic copper deficiency. exposure: 50 mg elemental zinc/day as gluconate, with or without 50 mg iron/day as ferrous sulfate monohydrate. cross_nutrient: Copper (affected_nutrient); Serum zinc concentration (increased_marker); Erythrocyte copper/zinc superoxide dismutase activity (decreased_marker) evidence_location: Indexed primary abstract. evidence_span: {"source_cache": "artifacts/zinc-clinical-sources/yadrick1989.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443", "utf8_bytes": 969} [zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. The study found no significant vitamin-C-period effect on copper absorption, retention, serum copper or ceruloplasmin protein despite the oxidase-activity change.

    L-Ascorbic acid → Whole-body copper retention source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/copper-research/3694287.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68", "start_char": 0, "end_char": 1031, "text_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68"}
    experimental_model
    Controlled sequential dietary vitamin C intervention
    exposure
    Fourteen-week feeding study: 65, 5, 605 and 5 mg vitamin C/day in successive periods
    limitations
    Short sequential study; ceruloplasmin activity differs from protein concentration and whole-body copper stores. No universal vitamin C threshold is established.
    nutrient_topic
    Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
    organism
    Human men
    plain_language
    The activity change did not demonstrate loss of body copper.
    primary_references
    [copper-p3694287] Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. (1987). https://pubmed.ncbi.nlm.nih.gov/3694287/ DOI: 10.1093/jn/117.12.2109
    tissue_or_cell_type
    Copper absorption, retention and circulating markers
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1118–1129

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled sequential dietary vitamin C intervention · source_derived_draft · unverified_draft

    ### copper-ascorbate-copper-retention The study found no significant vitamin-C-period effect on copper absorption, retention, serum copper or ceruloplasmin protein despite the oxidase-activity change. Condition category: biomarker_context nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: The activity change did not demonstrate loss of body copper. organism: Human men tissue_or_cell_type: Copper absorption, retention and circulating markers experimental_model: Controlled sequential dietary vitamin C intervention limitations: Short sequential study; ceruloplasmin activity differs from protein concentration and whole-body copper stores. No universal vitamin C threshold is established. exposure: Fourteen-week feeding study: 65, 5, 605 and 5 mg vitamin C/day in successive periods evidence_span: {"source_cache": "artifacts/copper-research/3694287.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68", "start_char": 0, "end_char": 1031, "text_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68"} [copper-p3694287] Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. (1987). https://pubmed.ncbi.nlm.nih.gov/3694287/ DOI: 10.1093/jn/117.12.2109
    Complete structured claim and evidence

  2. Low copper intake reduced ceruloplasmin activity and protein concentration; repletion raised plasma copper and ceruloplasmin protein.

    Copper → Circulating ceruloplasmin oxidase activity source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/copper-research/8988916.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b", "start_char": 0, "end_char": 1349, "text_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b"}
    experimental_model
    Metabolic-ward depletion and repletion study
    exposure
    Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days
    limitations
    Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations.
    nutrient_topic
    Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
    organism
    Human young men
    plain_language
    Both enzyme activity and its amount responded to copper supply.
    primary_references
    [copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72
    tissue_or_cell_type
    Plasma, urine and erythrocytes
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1339–1350

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Metabolic-ward depletion and repletion study · source_derived_draft · unverified_draft

    ### copper-human-lowcu-cp Low copper intake reduced ceruloplasmin activity and protein concentration; repletion raised plasma copper and ceruloplasmin protein. Condition category: nutrient_deficiency nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both enzyme activity and its amount responded to copper supply. organism: Human young men tissue_or_cell_type: Plasma, urine and erythrocytes experimental_model: Metabolic-ward depletion and repletion study limitations: Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations. exposure: Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days evidence_span: {"source_cache": "artifacts/copper-research/8988916.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b", "start_char": 0, "end_char": 1349, "text_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b"} [copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72
    Complete structured claim and evidence

  3. Copper administration increased erythrocyte size and leukocyte counts in the reported index patient; the authors also reported correction of hypoceruloplasminemia in additional zinc-treated patients.

    Copper → Erythrocyte mean cell volume source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Zinc (prior_exposure); Blood leukocyte count (increased_endpoint); Serum ceruloplasmin concentration (responsive_marker)
    evidence_location
    Indexed primary abstract.
    evidence_span
    {"source_cache": "artifacts/zinc-clinical-sources/prasad1978.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f", "utf8_bytes": 487}
    experimental_model
    Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy
    exposure
    Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered.
    limitations
    Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Homo sapiens
    plain_language
    Copper replacement improved the reported blood-cell abnormalities.
    primary_references
    [zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. (1978). https://pubmed.ncbi.nlm.nih.gov/359844/ DOI: 10.1001/jama.1978.03290200044019
    tissue_or_cell_type
    Blood copper and hematology
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1422–1435

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy · source_derived_draft · unverified_draft

    ### zn-clin-copper-response Copper administration increased erythrocyte size and leukocyte counts in the reported index patient; the authors also reported correction of hypoceruloplasminemia in additional zinc-treated patients. Condition category: nutrient_deficiency nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Copper replacement improved the reported blood-cell abnormalities. organism: Homo sapiens tissue_or_cell_type: Blood copper and hematology experimental_model: Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy limitations: Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio. exposure: Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered. cross_nutrient: Zinc (prior_exposure); Blood leukocyte count (increased_endpoint); Serum ceruloplasmin concentration (responsive_marker) evidence_location: Indexed primary abstract. evidence_span: {"source_cache": "artifacts/zinc-clinical-sources/prasad1978.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f", "utf8_bytes": 487} [zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. (1978). https://pubmed.ncbi.nlm.nih.gov/359844/ DOI: 10.1001/jama.1978.03290200044019
    Complete structured claim and evidence

  4. An adult with sickle cell anemia developed hypocupremia after two years of zinc therapy, accompanied by microcytosis and relative neutropenia. Additional zinc-treated patients had varying hypoceruloplasminemia.

    Zinc → Plasma copper concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Copper (deficient_nutrient); Erythrocyte mean cell volume (reduced_endpoint); Blood neutrophil count (reduced_endpoint); Serum ceruloplasmin concentration (associated_marker)
    evidence_location
    Indexed primary abstract.
    evidence_span
    {"source_cache": "artifacts/zinc-clinical-sources/prasad1978.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f", "utf8_bytes": 487}
    experimental_model
    Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy
    exposure
    Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered.
    limitations
    Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio.
    nutrient_topic
    Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
    organism
    Homo sapiens
    plain_language
    Long zinc treatment was associated with copper shortage and blood-cell changes.
    primary_references
    [zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. (1978). https://pubmed.ncbi.nlm.nih.gov/359844/ DOI: 10.1001/jama.1978.03290200044019
    tissue_or_cell_type
    Blood copper and hematology
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1407–1420

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy · source_derived_draft · unverified_draft

    ### zn-clin-hypocupremia An adult with sickle cell anemia developed hypocupremia after two years of zinc therapy, accompanied by microcytosis and relative neutropenia. Additional zinc-treated patients had varying hypoceruloplasminemia. Condition category: nutrient_deficiency nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Long zinc treatment was associated with copper shortage and blood-cell changes. organism: Homo sapiens tissue_or_cell_type: Blood copper and hematology experimental_model: Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy limitations: Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio. exposure: Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered. cross_nutrient: Copper (deficient_nutrient); Erythrocyte mean cell volume (reduced_endpoint); Blood neutrophil count (reduced_endpoint); Serum ceruloplasmin concentration (associated_marker) evidence_location: Indexed primary abstract. evidence_span: {"source_cache": "artifacts/zinc-clinical-sources/prasad1978.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f", "utf8_bytes": 487} [zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. (1978). https://pubmed.ncbi.nlm.nih.gov/359844/ DOI: 10.1001/jama.1978.03290200044019
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

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