{"id":"a9aac534-b7b0-5cb9-9688-c6955412b93a","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-copper-response","predicate":"administration_increased","statement":"Copper administration increased erythrocyte size and leukocyte counts in the reported index patient; the authors also reported correction of hypoceruloplasminemia in additional zinc-treated patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"875f7723-237c-52d4-8a2c-c49c6820d6a7","mechanism_event_label":"Copper replacement improved the reported blood-cell abnormalities.","subject":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"object":{"id":"aa4f9545-abea-55c8-ab10-6ec530caa23f","slug":"erythrocyte-mean-cell-volume","display_name":"Erythrocyte mean cell volume","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"875f7723-237c-52d4-8a2c-c49c6820d6a7","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-copper-response-event","event_type":"observed_intervention","label":"Copper replacement improved the reported blood-cell abnormalities.","description":"Copper administration increased erythrocyte size and leukocyte counts in the reported index patient; the authors also reported correction of hypoceruloplasminemia in additional zinc-treated patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"prior_exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b76bbd99-8ef9-5242-915f-6240d9a80149","slug":"blood-leukocyte-count","display_name":"Blood leukocyte count","entity_type_key":"cellular_process"},"role":"increased_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"52c51470-f6c6-55ad-8d48-21de3c6799d7","slug":"serum-ceruloplasmin-concentration","display_name":"Serum ceruloplasmin concentration","entity_type_key":"cellular_process"},"role":"responsive_marker","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"aa4f9545-abea-55c8-ab10-6ec530caa23f","slug":"erythrocyte-mean-cell-volume","display_name":"Erythrocyte mean cell volume","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Zinc (prior_exposure); Blood leukocyte count (increased_endpoint); Serum ceruloplasmin concentration (responsive_marker)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/prasad1978.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f\", \"utf8_bytes\": 487}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Copper replacement improved the reported blood-cell abnormalities.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. 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Does not establish incidence or a universal zinc:copper supplement ratio.\nexposure: Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered.\ncross_nutrient: Zinc (prior_exposure); Blood leukocyte count (increased_endpoint); Serum ceruloplasmin concentration (responsive_marker)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/prasad1978.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f\", \"utf8_bytes\": 487}\n[zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. 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