Component
Plasma copper concentration
Plasma copper concentration; read each linked claim for the measured context and model.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The low-copper period reduced plasma copper in the eleven-man metabolic-ward study.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/8988916.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b", "start_char": 0, "end_char": 1349, "text_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b"}
- experimental_model
- Metabolic-ward depletion and repletion study
- exposure
- Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days
- limitations
- Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human young men
- plain_language
- Sustained low intake changed the circulating copper measurement.
- primary_references
- [copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72
- tissue_or_cell_type
- Plasma, urine and erythrocytes
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1326–1337
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Metabolic-ward depletion and repletion study · source_derived_draft · unverified_draft
### copper-human-lowcu-plasma The low-copper period reduced plasma copper in the eleven-man metabolic-ward study. Condition category: nutrient_deficiency nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sustained low intake changed the circulating copper measurement. organism: Human young men tissue_or_cell_type: Plasma, urine and erythrocytes experimental_model: Metabolic-ward depletion and repletion study limitations: Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations. exposure: Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days evidence_span: {"source_cache": "artifacts/copper-research/8988916.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b", "start_char": 0, "end_char": 1349, "text_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b"} [copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72
Complete structured claim and evidenceAn adult with sickle cell anemia developed hypocupremia after two years of zinc therapy, accompanied by microcytosis and relative neutropenia. Additional zinc-treated patients had varying hypoceruloplasminemia.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Copper (deficient_nutrient); Erythrocyte mean cell volume (reduced_endpoint); Blood neutrophil count (reduced_endpoint); Serum ceruloplasmin concentration (associated_marker)
- evidence_location
- Indexed primary abstract.
- evidence_span
- {"source_cache": "artifacts/zinc-clinical-sources/prasad1978.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f", "utf8_bytes": 487}
- experimental_model
- Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy
- exposure
- Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered.
- limitations
- Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- Long zinc treatment was associated with copper shortage and blood-cell changes.
- primary_references
- [zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. (1978). https://pubmed.ncbi.nlm.nih.gov/359844/ DOI: 10.1001/jama.1978.03290200044019
- tissue_or_cell_type
- Blood copper and hematology
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 1407–1420
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy · source_derived_draft · unverified_draft
### zn-clin-hypocupremia An adult with sickle cell anemia developed hypocupremia after two years of zinc therapy, accompanied by microcytosis and relative neutropenia. Additional zinc-treated patients had varying hypoceruloplasminemia. Condition category: nutrient_deficiency nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Long zinc treatment was associated with copper shortage and blood-cell changes. organism: Homo sapiens tissue_or_cell_type: Blood copper and hematology experimental_model: Clinical case and additional observations in adults with sickle cell anemia receiving zinc therapy limitations: Case evidence in a particular disease setting; dose and formulation are not verified from the abstract. Does not establish incidence or a universal zinc:copper supplement ratio. exposure: Index patient received zinc as an antisickling intervention for two years; copper was subsequently administered. cross_nutrient: Copper (deficient_nutrient); Erythrocyte mean cell volume (reduced_endpoint); Blood neutrophil count (reduced_endpoint); Serum ceruloplasmin concentration (associated_marker) evidence_location: Indexed primary abstract. evidence_span: {"source_cache": "artifacts/zinc-clinical-sources/prasad1978.abstract.txt", "locator": "Primary indexed abstract; complete local file", "file_sha256": "7c4b85a9dd24c3e3bfd04414c0add5d0fa2bcc8c15b5e46bded351e2a2f01e3f", "utf8_bytes": 487} [zn-clin-prasad1978] Hypocupremia induced by zinc therapy in adults. (1978). https://pubmed.ncbi.nlm.nih.gov/359844/ DOI: 10.1001/jama.1978.03290200044019
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.