{"id":"aa3976a5-6b99-5d28-bfde-7f95af1c2d19","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-human-lowcu-plasma","predicate":"dietary_depletion_reduces","statement":"The low-copper period reduced plasma copper in the eleven-man metabolic-ward study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8dc3b75b-3d1b-5728-b26f-b555d603afe7","mechanism_event_label":"Sustained low intake changed the circulating copper measurement.","subject":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"object":{"id":"db7bc59e-c019-5547-a007-d0d77633bf00","slug":"plasma-copper-concentration","display_name":"Plasma copper concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8dc3b75b-3d1b-5728-b26f-b555d603afe7","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-human-lowcu-plasma-event","event_type":"observed_intervention","label":"Sustained low intake changed the circulating copper measurement.","description":"The low-copper period reduced plasma copper in the eleven-man metabolic-ward study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"db7bc59e-c019-5547-a007-d0d77633bf00","slug":"plasma-copper-concentration","display_name":"Plasma copper concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/8988916.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b\", \"start_char\": 0, \"end_char\": 1349, \"text_sha256\": \"0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-ward depletion and repletion study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human young men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sustained low intake changed the circulating copper measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma, urine and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"104d38a4-3613-5f5f-b9a7-d8156583a142","evidence_kind":"source_excerpt","locator":"Lines 1326-1337","start_line":1326,"end_line":1337,"excerpt":"### copper-human-lowcu-plasma\nThe low-copper period reduced plasma copper in the eleven-man metabolic-ward study.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Sustained low intake changed the circulating copper measurement.\norganism: Human young men\ntissue_or_cell_type: Plasma, urine and erythrocytes\nexperimental_model: Metabolic-ward depletion and repletion study\nlimitations: Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations.\nexposure: Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days\nevidence_span: {\"source_cache\": \"artifacts/copper-research/8988916.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b\", \"start_char\": 0, \"end_char\": 1349, \"text_sha256\": \"0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b\"}\n[copper-p8988916] Copper status of young men consuming a low-copper diet. 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