{"id":"8aa759e3-d825-5831-aa1c-a7111c72e9d5","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-ceruloplasmin-null","predicate":"did_not_detectably_change","statement":"Serum ceruloplasmin was unchanged in both intervention groups despite lower erythrocyte Cu/Zn-superoxide dismutase activity; serum zinc rose in both groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"de1973c2-ece4-5899-bc8d-5bd2388305c9","mechanism_event_label":"A rising zinc blood level and unchanged ceruloplasmin did not capture every functional change.","subject":{"id":"8410d352-35ea-518e-b738-4c10962b11ed","slug":"zinc-gluconate","display_name":"Zinc gluconate","entity_type_key":"chemical_species"},"object":{"id":"52c51470-f6c6-55ad-8d48-21de3c6799d7","slug":"serum-ceruloplasmin-concentration","display_name":"Serum ceruloplasmin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"de1973c2-ece4-5899-bc8d-5bd2388305c9","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-ceruloplasmin-null-event","event_type":"observed_intervention","label":"A rising zinc blood level and unchanged ceruloplasmin did not capture every functional change.","description":"Serum ceruloplasmin was unchanged in both intervention groups despite lower erythrocyte Cu/Zn-superoxide dismutase activity; serum zinc rose in both groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d78e85a6-2637-50ff-8935-c946a7fc8761","slug":"serum-zinc-concentration","display_name":"Serum zinc concentration","entity_type_key":"cellular_process"},"role":"increased_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"09fadb77-b222-5d11-b365-077675f16d13","slug":"erythrocyte-cu-zn-sod-activity","display_name":"Erythrocyte copper/zinc superoxide dismutase activity","entity_type_key":"cellular_process"},"role":"decreased_marker","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8410d352-35ea-518e-b738-4c10962b11ed","slug":"zinc-gluconate","display_name":"Zinc gluconate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"52c51470-f6c6-55ad-8d48-21de3c6799d7","slug":"serum-ceruloplasmin-concentration","display_name":"Serum ceruloplasmin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Copper (affected_nutrient); Serum zinc concentration (increased_marker); Erythrocyte copper/zinc superoxide dismutase activity (decreased_marker)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/yadrick1989.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\", \"utf8_bytes\": 969}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten-week zinc or zinc-plus-iron intervention in adult women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"50 mg elemental zinc/day as gluconate, with or without 50 mg iron/day as ferrous sulfate monohydrate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reported comparisons are within-group pretreatment versus 10 weeks, not placebo-adjusted effects. ESOD is a functional biomarker, not a diagnosis of symptomatic copper deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A rising zinc blood level and unchanged ceruloplasmin did not capture every functional change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5150899d-00df-5649-b4c7-f8e904fecde2","evidence_kind":"source_excerpt","locator":"Lines 1211-1224","start_line":1211,"end_line":1224,"excerpt":"### zn-clin-ceruloplasmin-null\nSerum ceruloplasmin was unchanged in both intervention groups despite lower erythrocyte Cu/Zn-superoxide dismutase activity; serum zinc rose in both groups.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A rising zinc blood level and unchanged ceruloplasmin did not capture every functional change.\norganism: Homo sapiens\ntissue_or_cell_type: Blood and erythrocytes\nexperimental_model: Ten-week zinc or zinc-plus-iron intervention in adult women\nlimitations: Reported comparisons are within-group pretreatment versus 10 weeks, not placebo-adjusted effects. ESOD is a functional biomarker, not a diagnosis of symptomatic copper deficiency.\nexposure: 50 mg elemental zinc/day as gluconate, with or without 50 mg iron/day as ferrous sulfate monohydrate.\ncross_nutrient: Copper (affected_nutrient); Serum zinc concentration (increased_marker); Erythrocyte copper/zinc superoxide dismutase activity (decreased_marker)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/yadrick1989.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"e2d70d43dded75edb026cac237f238d9e59399db6094098796e169f20e819443\", \"utf8_bytes\": 969}\n[zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","model_system":"Ten-week zinc or zinc-plus-iron intervention in adult women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-yadrick1989] Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. (1989). https://pubmed.ncbi.nlm.nih.gov/2912000/ DOI: 10.1093/ajcn/49.1.145","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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