Component
Circulating ceruloplasmin oxidase activity
Circulating ceruloplasmin oxidase activity. Species, exposure and limitations are retained in each linked claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 605 mg/day vitamin C period reduced ceruloplasmin oxidase activity by about 21% in the controlled feeding study.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/3694287.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68", "start_char": 0, "end_char": 1031, "text_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68"}
- experimental_model
- Controlled sequential dietary vitamin C intervention
- exposure
- Fourteen-week feeding study: 65, 5, 605 and 5 mg vitamin C/day in successive periods
- limitations
- Short sequential study; ceruloplasmin activity differs from protein concentration and whole-body copper stores. No universal vitamin C threshold is established.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human men
- plain_language
- A copper-related enzyme measurement changed with vitamin C intake.
- primary_references
- [copper-p3694287] Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. (1987). https://pubmed.ncbi.nlm.nih.gov/3694287/ DOI: 10.1093/jn/117.12.2109
- tissue_or_cell_type
- Copper absorption, retention and circulating markers
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1105–1116
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled sequential dietary vitamin C intervention · source_derived_draft · unverified_draft
### copper-ascorbate-cp-oxidase The 605 mg/day vitamin C period reduced ceruloplasmin oxidase activity by about 21% in the controlled feeding study. Condition category: biomarker_context nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: A copper-related enzyme measurement changed with vitamin C intake. organism: Human men tissue_or_cell_type: Copper absorption, retention and circulating markers experimental_model: Controlled sequential dietary vitamin C intervention limitations: Short sequential study; ceruloplasmin activity differs from protein concentration and whole-body copper stores. No universal vitamin C threshold is established. exposure: Fourteen-week feeding study: 65, 5, 605 and 5 mg vitamin C/day in successive periods evidence_span: {"source_cache": "artifacts/copper-research/3694287.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68", "start_char": 0, "end_char": 1031, "text_sha256": "37e70fcbc672023cd6c3616b4a1171c6ded4caafe4e3c14d4f80c6abca490e68"} [copper-p3694287] Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. (1987). https://pubmed.ncbi.nlm.nih.gov/3694287/ DOI: 10.1093/jn/117.12.2109
Complete structured claim and evidenceCeruloplasmin oxidase activity decreased during 1500 mg/day vitamin C supplementation; the serum copper decline was not statistically significant.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/6837490.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03", "start_char": 0, "end_char": 1026, "text_sha256": "628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03"}
- experimental_model
- Within-person vitamin C supplementation and withdrawal study
- exposure
- 1500 mg vitamin C/day for 64 days on self-selected diets
- limitations
- No independent placebo control; measured values remained within cited physiological ranges, and serum copper decline during supplementation was not significant.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human men
- plain_language
- Enzyme activity was more responsive than the copper concentration measurement in this small study.
- primary_references
- [copper-p6837490] Influence of ascorbic acid supplementation on copper status in young adult men. (1983). https://pubmed.ncbi.nlm.nih.gov/6837490/ DOI: 10.1093/ajcn/37.4.553
- tissue_or_cell_type
- Circulating copper and ceruloplasmin activity
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1131–1142
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Within-person vitamin C supplementation and withdrawal study · source_derived_draft · unverified_draft
### copper-high-vitc-cp-activity Ceruloplasmin oxidase activity decreased during 1500 mg/day vitamin C supplementation; the serum copper decline was not statistically significant. Condition category: biomarker_context nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Enzyme activity was more responsive than the copper concentration measurement in this small study. organism: Human men tissue_or_cell_type: Circulating copper and ceruloplasmin activity experimental_model: Within-person vitamin C supplementation and withdrawal study limitations: No independent placebo control; measured values remained within cited physiological ranges, and serum copper decline during supplementation was not significant. exposure: 1500 mg vitamin C/day for 64 days on self-selected diets evidence_span: {"source_cache": "artifacts/copper-research/6837490.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03", "start_char": 0, "end_char": 1026, "text_sha256": "628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03"} [copper-p6837490] Influence of ascorbic acid supplementation on copper status in young adult men. (1983). https://pubmed.ncbi.nlm.nih.gov/6837490/ DOI: 10.1093/ajcn/37.4.553
Complete structured claim and evidenceLow copper intake reduced ceruloplasmin activity and protein concentration; repletion raised plasma copper and ceruloplasmin protein.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/copper-research/8988916.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b", "start_char": 0, "end_char": 1349, "text_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b"}
- experimental_model
- Metabolic-ward depletion and repletion study
- exposure
- Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days
- limitations
- Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations.
- nutrient_topic
- Copper research collection; topical membership is not evidence of a direct dietary effect. · Copper
- organism
- Human young men
- plain_language
- Both enzyme activity and its amount responded to copper supply.
- primary_references
- [copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72
- tissue_or_cell_type
- Plasma, urine and erythrocytes
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17) · lines 1339–1350
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Metabolic-ward depletion and repletion study · source_derived_draft · unverified_draft
### copper-human-lowcu-cp Low copper intake reduced ceruloplasmin activity and protein concentration; repletion raised plasma copper and ceruloplasmin protein. Condition category: nutrient_deficiency nutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both enzyme activity and its amount responded to copper supply. organism: Human young men tissue_or_cell_type: Plasma, urine and erythrocytes experimental_model: Metabolic-ward depletion and repletion study limitations: Small controlled feeding study; regimen-specific changes are not universal diagnostic thresholds or modern intake recommendations. exposure: Eleven men: 0.66 mg copper/day for 24 days, 0.38 for 42 days, then 2.49 for 24 days evidence_span: {"source_cache": "artifacts/copper-research/8988916.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b", "start_char": 0, "end_char": 1349, "text_sha256": "0be30b28f91bce964b969517de4b15eb3ba5905a6f5f1f0a9dc4afa29e9d101b"} [copper-p8988916] Copper status of young men consuming a low-copper diet. (1997). https://pubmed.ncbi.nlm.nih.gov/8988916/ DOI: 10.1093/ajcn/65.1.72
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.