{"id":"2c2d8009-de24-5ef3-acb7-d71359077a85","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-high-vitc-cp-activity","predicate":"associated_with_lower","statement":"Ceruloplasmin oxidase activity decreased during 1500 mg/day vitamin C supplementation; the serum copper decline was not statistically significant.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8bcb44df-47c1-5b79-8fa0-d1cfd32f5122","mechanism_event_label":"Enzyme activity was more responsive than the copper concentration measurement in this small study.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"ef7ac2c4-5d73-5c0a-809b-222a568c312a","slug":"ceruloplasmin-oxidase-activity","display_name":"Circulating ceruloplasmin oxidase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8bcb44df-47c1-5b79-8fa0-d1cfd32f5122","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-high-vitc-cp-activity-event","event_type":"observed_intervention","label":"Enzyme activity was more responsive than the copper concentration measurement in this small study.","description":"Ceruloplasmin oxidase activity decreased during 1500 mg/day vitamin C supplementation; the serum copper decline was not statistically significant.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ef7ac2c4-5d73-5c0a-809b-222a568c312a","slug":"ceruloplasmin-oxidase-activity","display_name":"Circulating ceruloplasmin oxidase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/6837490.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03\", \"start_char\": 0, \"end_char\": 1026, \"text_sha256\": \"628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Within-person vitamin C supplementation and withdrawal study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1500 mg vitamin C/day for 64 days on self-selected diets","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No independent placebo control; measured values remained within cited physiological ranges, and serum copper decline during supplementation was not significant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Enzyme activity was more responsive than the copper concentration measurement in this small study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p6837490] Influence of ascorbic acid supplementation on copper status in young adult men. (1983). https://pubmed.ncbi.nlm.nih.gov/6837490/ DOI: 10.1093/ajcn/37.4.553","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating copper and ceruloplasmin activity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"117e8b00-be7f-5b78-9db1-bdfe288e0961","evidence_kind":"source_excerpt","locator":"Lines 1131-1142","start_line":1131,"end_line":1142,"excerpt":"### copper-high-vitc-cp-activity\nCeruloplasmin oxidase activity decreased during 1500 mg/day vitamin C supplementation; the serum copper decline was not statistically significant.\nCondition category: biomarker_context\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Enzyme activity was more responsive than the copper concentration measurement in this small study.\norganism: Human men\ntissue_or_cell_type: Circulating copper and ceruloplasmin activity\nexperimental_model: Within-person vitamin C supplementation and withdrawal study\nlimitations: No independent placebo control; measured values remained within cited physiological ranges, and serum copper decline during supplementation was not significant.\nexposure: 1500 mg vitamin C/day for 64 days on self-selected diets\nevidence_span: {\"source_cache\": \"artifacts/copper-research/6837490.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03\", \"start_char\": 0, \"end_char\": 1026, \"text_sha256\": \"628dd5cb00ff83cf6d31ff973073a19041de727a370d8652715bb6452b29bc03\"}\n[copper-p6837490] Influence of ascorbic acid supplementation on copper status in young adult men. 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