{"id":"574209e6-ea08-5169-80ef-c376e9048ba8","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-bypass-cp-timecourse","predicate":"postoperative_course_associated_with","statement":"In the sixteen-person longitudinal group, plasma copper and ceruloplasmin declined over follow-up, with a reported copper-deficiency incidence of 18.8%.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5aa10633-eb51-54a8-a091-b72305f545c1","mechanism_event_label":"Following the same people over time detected falling copper-related measures.","subject":{"id":"b1c3755d-8dd5-5fc3-9fb1-cd322f36e09d","slug":"low-copper-status","display_name":"Biochemically low copper status","entity_type_key":"cellular_process"},"object":{"id":"52c51470-f6c6-55ad-8d48-21de3c6799d7","slug":"serum-ceruloplasmin-concentration","display_name":"Serum ceruloplasmin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5aa10633-eb51-54a8-a091-b72305f545c1","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-bypass-cp-timecourse-event","event_type":"observed_intervention","label":"Following the same people over time detected falling copper-related measures.","description":"In the sixteen-person longitudinal group, plasma copper and ceruloplasmin declined over follow-up, with a reported copper-deficiency incidence of 18.8%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b1c3755d-8dd5-5fc3-9fb1-cd322f36e09d","slug":"low-copper-status","display_name":"Biochemically low copper status","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"52c51470-f6c6-55ad-8d48-21de3c6799d7","slug":"serum-ceruloplasmin-concentration","display_name":"Serum ceruloplasmin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/21876546.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\", \"start_char\": 0, \"end_char\": 1842, \"text_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Post-Roux-en-Y clinic cohort and longitudinal subset","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"136-person clinic cohort; separate longitudinal group of sixteen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Clinic selection and small longitudinal sample limit generalization; the study does not establish the sole molecular cause of every postoperative symptom.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Following the same people over time detected falling copper-related measures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and clinical findings after gastric bypass","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b185652d-6cf1-5072-892e-9231d0473d15","evidence_kind":"source_excerpt","locator":"Lines 1404-1415","start_line":1404,"end_line":1415,"excerpt":"### copper-bypass-cp-timecourse\nIn the sixteen-person longitudinal group, plasma copper and ceruloplasmin declined over follow-up, with a reported copper-deficiency incidence of 18.8%.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Following the same people over time detected falling copper-related measures.\norganism: Human\ntissue_or_cell_type: Blood and clinical findings after gastric bypass\nexperimental_model: Post-Roux-en-Y clinic cohort and longitudinal subset\nlimitations: Clinic selection and small longitudinal sample limit generalization; the study does not establish the sole molecular cause of every postoperative symptom.\nexposure: 136-person clinic cohort; separate longitudinal group of sixteen\nevidence_span: {\"source_cache\": \"artifacts/copper-research/21876546.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\", \"start_char\": 0, \"end_char\": 1842, \"text_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\"}\n[copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159","model_system":"Post-Roux-en-Y clinic cohort and longitudinal subset","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}