Component

Plasma thiamine concentration

Plasma thiamine concentration

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Baseline plasma thiamine correlated with erythrocyte ThDP at Spearman r = 0.41 in the 196 women.

    Plasma thiamine concentration → Erythrocyte thiamine diphosphate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_location
    Results 3.2; Table 2
    evidence_span
    Spearman correlation coefficients
    experimental_model
    196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.
    exposure
    Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women
    limitations
    Cross-sectional correlation in healthy women does not validate a plasma cutoff for Wernicke encephalopathy.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    Plasma and red-cell markers were related, but they captured different biological variation.
    primary_references
    [mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676
    tissue_or_cell_type
    Plasma and erythrocytes
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1451–1463

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays. · source_derived_draft · unverified_draft

    ### thiamine-def-plasma-erythrocyte-imperfect-correlation Baseline plasma thiamine correlated with erythrocyte ThDP at Spearman r = 0.41 in the 196 women. Condition category: biomarker_context nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Plasma and red-cell markers were related, but they captured different biological variation. organism: Homo sapiens tissue_or_cell_type: Plasma and erythrocytes experimental_model: 196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays. limitations: Cross-sectional correlation in healthy women does not validate a plasma cutoff for Wernicke encephalopathy. evidence_location: Results 3.2; Table 2 evidence_span: Spearman correlation coefficients exposure: Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women [mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676
    Complete structured claim and evidence

What acts on it

  1. Plasma thiamine increased significantly in both fortified-fish-sauce groups and was more responsive than the other measured thiamine forms.

    Thiamine (vitamin B1) → Plasma thiamine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_location
    Results 3.3; Table 3; Discussion
    evidence_span
    plasma thiamine was the most responsive measure
    experimental_model
    196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.
    exposure
    Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women
    limitations
    An intake-responsive marker does not establish brain adequacy, clinical benefit or interchangeability with erythrocyte ThDP.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Homo sapiens
    plain_language
    The plasma measurement was sensitive to added dietary thiamine in this population.
    primary_references
    [mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676
    tissue_or_cell_type
    Plasma
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1437–1449

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays. · source_derived_draft · unverified_draft

    ### thiamine-def-plasma-thiamine-intake-response Plasma thiamine increased significantly in both fortified-fish-sauce groups and was more responsive than the other measured thiamine forms. Condition category: biomarker_context nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The plasma measurement was sensitive to added dietary thiamine in this population. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: 196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays. limitations: An intake-responsive marker does not establish brain adequacy, clinical benefit or interchangeability with erythrocyte ThDP. evidence_location: Results 3.3; Table 3; Discussion evidence_span: plasma thiamine was the most responsive measure exposure: Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women [mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676
    Complete structured claim and evidence

  2. Electronic health record analysis suggested that thiamine laboratory values are reduced in individuals receiving prescription drugs that significantly inhibit ThTR-2, particularly in vulnerable populations such as individuals with alcoholism.

    Human thiamine transporter 2 / SLC19A3 → Plasma thiamine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/metformin-research/31764942.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "21758b02cd824f37a6e1e076657c0cf72d08cc6babcb66773613f129dc13f15b", "start_char": 0, "end_char": 1829, "text_sha256": "21758b02cd824f37a6e1e076657c0cf72d08cc6babcb66773613f129dc13f15b"}
    experimental_model
    High-throughput screen of 1360 compounds, in-silico modelling and electronic health record analysis
    exposure
    Inhibition kinetics with IC50 values and predicted intestinal concentrations
    limitations
    A screen plus a records analysis, not a trial. The trial termination cited as motivation involved a different, more potent inhibitor.
    nutrient_topic
    Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. · Metformin
    organism
    Human transporter and human health records
    plain_language
    In real records, people on these drugs had lower vitamin B1, most of all those already at risk.
    primary_references
    [metformin-p31764942] Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). (2020). https://pubmed.ncbi.nlm.nih.gov/31764942/ DOI: 10.1093/ajcn/nqz255
    tissue_or_cell_type
    Intestinal thiamine absorption
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Metformin: transport, molecular targets, gut mechanisms and nutrient interactions (2026-09-19) · lines 1334–1345

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · High-throughput screen of 1360 compounds, in-silico modelling and electronic health record analysis · source_derived_draft · unverified_draft

    ### metformin-thtr2-records-signal Electronic health record analysis suggested that thiamine laboratory values are reduced in individuals receiving prescription drugs that significantly inhibit ThTR-2, particularly in vulnerable populations such as individuals with alcoholism. Condition category: biomarker_context nutrient_topic: Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake. plain_language: In real records, people on these drugs had lower vitamin B1, most of all those already at risk. organism: Human transporter and human health records tissue_or_cell_type: Intestinal thiamine absorption experimental_model: High-throughput screen of 1360 compounds, in-silico modelling and electronic health record analysis limitations: A screen plus a records analysis, not a trial. The trial termination cited as motivation involved a different, more potent inhibitor. exposure: Inhibition kinetics with IC50 values and predicted intestinal concentrations evidence_span: {"source_cache": "artifacts/metformin-research/31764942.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "21758b02cd824f37a6e1e076657c0cf72d08cc6babcb66773613f129dc13f15b", "start_char": 0, "end_char": 1829, "text_sha256": "21758b02cd824f37a6e1e076657c0cf72d08cc6babcb66773613f129dc13f15b"} [metformin-p31764942] Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). (2020). https://pubmed.ncbi.nlm.nih.gov/31764942/ DOI: 10.1093/ajcn/nqz255
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively.

    Human diabetes status in the specified observational comparison → Renal clearance of thiamine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    curation_topic
    thiamine · Thiamine (vitamin B1)
    experimental_condition
    Healthy control group Diabetes status · Human diabetes status in the specified observational comparison Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Diabetes status", "comparator": "Healthy control group", "endpoint": "Renal thiamine clearance", "effect_direction": "increase", "combination": "single", "conditions": [{"entity_slug": "human-diabetes-study-state", "state": "Diabetes status"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    26 type-1 and 48 type-2 patients versus 20 healthy controls
    limitations
    Cross-sectional association; not proof that dietary deficiency caused diabetes. Erythrocyte transporter changes complicate status assessment.
    primary_references
    Thornalley et al. 2007; PMID:17676306; PMCID:PMC1998885; https://pubmed.ncbi.nlm.nih.gov/17676306/
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Diabetes cascade: targeted primary-source supplement · lines 27–27

    See claim-local references; curated paraphrases reviewed 2026-09-20. · supports · 26 type-1 and 48 type-2 patients versus 20 healthy controls · source_derived_draft · unverified_draft

    Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively. Model: 26 type-1 and 48 type-2 patients versus 20 healthy controls. Limits: Cross-sectional association; not proof that dietary deficiency caused diabetes. Erythrocyte transporter changes complicate status assessment. Primary reference: Thornalley et al. 2007; PMID:17676306; PMCID:PMC1998885; https://pubmed.ncbi.nlm.nih.gov/17676306/
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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