{"id":"a2c6d569-9d3e-5df8-b2c6-6f68732bca50","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:diabetes-thiamine-clearance","predicate":"reported_comparison","statement":"Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fdc8e64f-39e3-56ae-ae67-5cf575eb2268","mechanism_event_label":"Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively.","subject":{"id":"6dac5780-f648-5dce-9e3c-f39f1c91c75c","slug":"human-diabetes-study-state","display_name":"Human diabetes status in the specified observational comparison","entity_type_key":"cellular_process"},"object":{"id":"a2103dcc-d86e-5a1d-ac84-6ad3cd196a58","slug":"renal-thiamine-clearance","display_name":"Renal clearance of thiamine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fdc8e64f-39e3-56ae-ae67-5cf575eb2268","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:diabetes-thiamine-clearance","event_type":"reported_comparison","label":"Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively.","description":"","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6dac5780-f648-5dce-9e3c-f39f1c91c75c","slug":"human-diabetes-study-state","display_name":"Human diabetes status in the specified observational comparison","entity_type_key":"cellular_process"},"role":"experimental_actor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a2103dcc-d86e-5a1d-ac84-6ad3cd196a58","slug":"renal-thiamine-clearance","display_name":"Renal clearance of thiamine","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0ac5f678-3376-5be2-afdd-ec75928e4998","slug":"plasma-thiamine-concentration","display_name":"Plasma thiamine concentration","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"curation_topic","value_text":"thiamine","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"experimental_condition","value_text":"Diabetes status","comparator":"Healthy control group","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"human-diabetes-study-state","display_name":"Human diabetes status in the specified observational comparison","entity_type_key":"cellular_process"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Diabetes status\", \"comparator\": \"Healthy control group\", \"endpoint\": \"Renal thiamine clearance\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": [{\"entity_slug\": \"human-diabetes-study-state\", \"state\": \"Diabetes status\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"26 type-1 and 48 type-2 patients versus 20 healthy controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cross-sectional association; not proof that dietary deficiency caused diabetes. Erythrocyte transporter changes complicate status assessment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Thornalley et al. 2007; PMID:17676306; PMCID:PMC1998885; https://pubmed.ncbi.nlm.nih.gov/17676306/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c432c3ec-2209-5ad7-b11c-fa5f3b215ea6","evidence_kind":"source_excerpt","locator":"Lines 27-27","start_line":27,"end_line":27,"excerpt":"Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively. Model: 26 type-1 and 48 type-2 patients versus 20 healthy controls. Limits: Cross-sectional association; not proof that dietary deficiency caused diabetes. Erythrocyte transporter changes complicate status assessment. Primary reference: Thornalley et al. 2007; PMID:17676306; PMCID:PMC1998885; https://pubmed.ncbi.nlm.nih.gov/17676306/","model_system":"26 type-1 and 48 type-2 patients versus 20 healthy controls","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curator paraphrase of the cited primary result; see stated access scope.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8600b90c-477e-569e-9666-09321af7bc9e","stable_key":"import-3ad23a58-d6a8-5554-81d6-9c83abd33087","title":"Diabetes cascade: targeted primary-source supplement","document_type":"imported_text","citation_label":"See claim-local references; curated paraphrases reviewed 2026-09-20.","file_path":"","sha256":"0a841d67ea40a5efea21157e1a5703488b8ef63e587eea50dacac19c67894cd4","revision_id":"0faa1a78-e820-559e-a23b-5e3939f9079e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}