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The trial termination cited as motivation involved a different, more potent inhibitor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Metformin research collection; topical membership is not evidence of a direct clinical effect, and pharmacological exposure is not dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"metformin","display_name":"Metformin","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human transporter and human health records","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In real records, people on these drugs had lower vitamin B1, most of all those already at risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[metformin-p31764942] Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). 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The trial termination cited as motivation involved a different, more potent inhibitor.\nexposure: Inhibition kinetics with IC50 values and predicted intestinal concentrations\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/31764942.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"21758b02cd824f37a6e1e076657c0cf72d08cc6babcb66773613f129dc13f15b\", \"start_char\": 0, \"end_char\": 1829, \"text_sha256\": \"21758b02cd824f37a6e1e076657c0cf72d08cc6babcb66773613f129dc13f15b\"}\n[metformin-p31764942] Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). (2020). https://pubmed.ncbi.nlm.nih.gov/31764942/ DOI: 10.1093/ajcn/nqz255","model_system":"High-throughput screen of 1360 compounds, in-silico modelling and electronic health record analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [metformin-p31764942] Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). 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