{"id":"f71fb0e2-c231-566a-8fdd-8dd4937e11be","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-plasma-erythrocyte-imperfect-correlation","predicate":"correlates-with","statement":"Baseline plasma thiamine correlated with erythrocyte ThDP at Spearman r = 0.41 in the 196 women.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1092a700-2cb7-5845-b203-d1010410837a","mechanism_event_label":"Plasma and red-cell markers were related, but they captured different biological variation.","subject":{"id":"0ac5f678-3376-5be2-afdd-ec75928e4998","slug":"plasma-thiamine-concentration","display_name":"Plasma thiamine concentration","entity_type_key":"cellular_process"},"object":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1092a700-2cb7-5845-b203-d1010410837a","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-plasma-erythrocyte-imperfect-correlation-event","event_type":"observed_intervention","label":"Plasma and red-cell markers were related, but they captured different biological variation.","description":"Baseline plasma thiamine correlated with erythrocyte ThDP at Spearman r = 0.41 in the 196 women.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"187db168-8028-5ce6-9f8b-4bc61ebad1a0","slug":"thiamine-diphosphate","display_name":"Thiamine diphosphate","entity_type_key":"small_molecule"},"role":"erythrocyte analyte","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0ac5f678-3376-5be2-afdd-ec75928e4998","slug":"plasma-thiamine-concentration","display_name":"Plasma thiamine concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Results 3.2; Table 2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"Spearman correlation coefficients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cross-sectional correlation in healthy women does not validate a plasma cutoff for Wernicke encephalopathy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Plasma and red-cell markers were related, but they captured different biological variation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"51f01019-0dad-53ce-8f48-49759dc328eb","evidence_kind":"source_excerpt","locator":"Lines 1451-1463","start_line":1451,"end_line":1463,"excerpt":"### thiamine-def-plasma-erythrocyte-imperfect-correlation\nBaseline plasma thiamine correlated with erythrocyte ThDP at Spearman r = 0.41 in the 196 women.\nCondition category: biomarker_context\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Plasma and red-cell markers were related, but they captured different biological variation.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma and erythrocytes\nexperimental_model: 196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.\nlimitations: Cross-sectional correlation in healthy women does not validate a plasma cutoff for Wernicke encephalopathy.\nevidence_location: Results 3.2; Table 2\nevidence_span: Spearman correlation coefficients\nexposure: Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women\n[mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676","model_system":"196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}