{"id":"b214fb67-13ba-54d5-b683-1845cdcc7031","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-plasma-thiamine-intake-response","predicate":"fortification-increases","statement":"Plasma thiamine increased significantly in both fortified-fish-sauce groups and was more responsive than the other measured thiamine forms.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8b5fad9e-b0b8-561b-aba0-d4198665567d","mechanism_event_label":"The plasma measurement was sensitive to added dietary thiamine in this population.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"0ac5f678-3376-5be2-afdd-ec75928e4998","slug":"plasma-thiamine-concentration","display_name":"Plasma thiamine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8b5fad9e-b0b8-561b-aba0-d4198665567d","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-plasma-thiamine-intake-response-event","event_type":"observed_intervention","label":"The plasma measurement was sensitive to added dietary thiamine in this population.","description":"Plasma thiamine increased significantly in both fortified-fish-sauce groups and was more responsive than the other measured thiamine forms.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"measured unphosphorylated plasma form","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0ac5f678-3376-5be2-afdd-ec75928e4998","slug":"plasma-thiamine-concentration","display_name":"Plasma thiamine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Results 3.3; Table 3; Discussion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"plasma thiamine was the most responsive measure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"An intake-responsive marker does not establish brain adequacy, clinical benefit or interchangeability with erythrocyte ThDP.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The plasma measurement was sensitive to added dietary thiamine in this population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"66f19eea-521f-508c-b484-3d05526dbbff","evidence_kind":"source_excerpt","locator":"Lines 1437-1449","start_line":1437,"end_line":1449,"excerpt":"### thiamine-def-plasma-thiamine-intake-response\nPlasma thiamine increased significantly in both fortified-fish-sauce groups and was more responsive than the other measured thiamine forms.\nCondition category: biomarker_context\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The plasma measurement was sensitive to added dietary thiamine in this population.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: 196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.\nlimitations: An intake-responsive marker does not establish brain adequacy, clinical benefit or interchangeability with erythrocyte ThDP.\nevidence_location: Results 3.3; Table 3; Discussion\nevidence_span: plasma thiamine was the most responsive measure\nexposure: Six-month thiamine-fortified fish-sauce intervention in healthy Cambodian women\n[mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676","model_system":"196 healthy rural Cambodian women aged 18-45; samples from a six-month thiamine-fortified fish-sauce intervention; plasma LC-MS/MS and erythrocyte HPLC assays.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mccann-2017-plasma-erythrocyte] Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women (2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5537791/ DOI: 10.3390/nu9070676","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}