Component
Human diabetes status in the specified observational comparison
Human diabetes status in the specified observational comparison
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- curation_topic
- thiamine · Thiamine (vitamin B1)
- experimental_condition
- Healthy control group Diabetes status · Human diabetes status in the specified observational comparison Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Diabetes status", "comparator": "Healthy control group", "endpoint": "Renal thiamine clearance", "effect_direction": "increase", "combination": "single", "conditions": [{"entity_slug": "human-diabetes-study-state", "state": "Diabetes status"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- 26 type-1 and 48 type-2 patients versus 20 healthy controls
- limitations
- Cross-sectional association; not proof that dietary deficiency caused diabetes. Erythrocyte transporter changes complicate status assessment.
- primary_references
- Thornalley et al. 2007; PMID:17676306; PMCID:PMC1998885; https://pubmed.ncbi.nlm.nih.gov/17676306/
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Diabetes cascade: targeted primary-source supplement · lines 27–27
See claim-local references; curated paraphrases reviewed 2026-09-20. · supports · 26 type-1 and 48 type-2 patients versus 20 healthy controls · source_derived_draft · unverified_draft
Renal thiamine clearance was 24-fold higher in type 1 and 16-fold higher in type 2 diabetes; plasma thiamine was 76% and 75% lower, respectively. Model: 26 type-1 and 48 type-2 patients versus 20 healthy controls. Limits: Cross-sectional association; not proof that dietary deficiency caused diabetes. Erythrocyte transporter changes complicate status assessment. Primary reference: Thornalley et al. 2007; PMID:17676306; PMCID:PMC1998885; https://pubmed.ncbi.nlm.nih.gov/17676306/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.