Component

Phosphorus

Phosphorus. Species, exposure and limitations are retained in each linked claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Reported serum FGF23 decreased during low-phosphate feeding and increased after oral phosphate loading in healthy men.

    Phosphorus → Circulating FGF23 assay result, molecular form unresolved source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/15613425.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2", "start_char": 0, "end_char": 1563, "text_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2"}
    experimental_model
    Controlled sequential dietary intervention
    exposure
    Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes
    limitations
    FGF23 assay form not resolved from the indexed abstract; circulating FGF23 result must not be read as a quantified cleavage ratio.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    object_scope
    FGF23 assay result; assay form unresolved from abstract
    organism
    Human
    plain_language
    Changing phosphorus exposure changed a hormone involved in phosphate handling.
    primary_references
    [phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. (2005). https://pubmed.ncbi.nlm.nih.gov/15613425/ DOI: 10.1210/jc.2004-1039
    tissue_or_cell_type
    29 healthy young men; serum hormones and renal handling

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 906–918

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled sequential dietary intervention · source_derived_draft · unverified_draft

    ### phosphorus-diet-fgf23 Reported serum FGF23 decreased during low-phosphate feeding and increased after oral phosphate loading in healthy men. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing phosphorus exposure changed a hormone involved in phosphate handling. organism: Human tissue_or_cell_type: 29 healthy young men; serum hormones and renal handling experimental_model: Controlled sequential dietary intervention limitations: FGF23 assay form not resolved from the indexed abstract; circulating FGF23 result must not be read as a quantified cleavage ratio. exposure: Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes object_scope: FGF23 assay result; assay form unresolved from abstract evidence_span: {"source_cache": "artifacts/phosphorus-research/15613425.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2", "start_char": 0, "end_char": 1563, "text_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2"} [phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. (2005). https://pubmed.ncbi.nlm.nih.gov/15613425/ DOI: 10.1210/jc.2004-1039
    Complete structured claim and evidence

  2. Diet-related FGF23 changes correlated inversely with maximal tubular phosphate reabsorption and calcitriol, and positively with urinary phosphate excretion.

    Phosphorus → Renal phosphate reabsorption source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/15613425.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2", "start_char": 0, "end_char": 1563, "text_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2"}
    experimental_model
    Controlled sequential dietary intervention
    exposure
    Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes
    limitations
    Phosphate intake and calcium/binder cointerventions are explicit; correlation of hormones with renal handling does not independently prove each mediator.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    The hormone, kidney and vitamin D responses moved together during the intervention.
    primary_references
    [phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. (2005). https://pubmed.ncbi.nlm.nih.gov/15613425/ DOI: 10.1210/jc.2004-1039
    tissue_or_cell_type
    29 healthy young men; serum hormones and renal handling

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 920–931

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled sequential dietary intervention · source_derived_draft · unverified_draft

    ### phosphorus-diet-renal-feedback Diet-related FGF23 changes correlated inversely with maximal tubular phosphate reabsorption and calcitriol, and positively with urinary phosphate excretion. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The hormone, kidney and vitamin D responses moved together during the intervention. organism: Human tissue_or_cell_type: 29 healthy young men; serum hormones and renal handling experimental_model: Controlled sequential dietary intervention limitations: Phosphate intake and calcium/binder cointerventions are explicit; correlation of hormones with renal handling does not independently prove each mediator. exposure: Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes evidence_span: {"source_cache": "artifacts/phosphorus-research/15613425.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2", "start_char": 0, "end_char": 1563, "text_sha256": "4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2"} [phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. (2005). https://pubmed.ncbi.nlm.nih.gov/15613425/ DOI: 10.1210/jc.2004-1039
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Intact FGF23 rose from 33 to 37 ng/L during the higher-phosphate/calcium regimen.

    Paired low/high phosphate and calcium diets in the 2010 study → Circulating biologically active intact FGF23 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"}
    experimental_model
    Paired 36-hour dietary interventions
    exposure
    Low/high phosphate and calcium diets, separated by a week
    limitations
    Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    The active hormone concentration also increased.
    primary_references
    [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    tissue_or_cell_type
    Ten healthy adults; serial serum measurements and 24-hour urine

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 946–957

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired 36-hour dietary interventions · source_derived_draft · unverified_draft

    ### phosphorus-mixed-diet-fgf23 Intact FGF23 rose from 33 to 37 ng/L during the higher-phosphate/calcium regimen. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The active hormone concentration also increased. organism: Human tissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine experimental_model: Paired 36-hour dietary interventions limitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter. exposure: Low/high phosphate and calcium diets, separated by a week evidence_span: {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"} [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    Complete structured claim and evidence

  2. Serum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen.

    Paired low/high phosphate and calcium diets in the 2010 study → Serum inorganic phosphate concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"}
    experimental_model
    Paired 36-hour dietary interventions
    exposure
    Low/high phosphate and calcium diets, separated by a week
    limitations
    Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    The combined dietary change raised the blood phosphate measurement.
    primary_references
    [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    tissue_or_cell_type
    Ten healthy adults; serial serum measurements and 24-hour urine

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 933–944

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired 36-hour dietary interventions · source_derived_draft · unverified_draft

    ### phosphorus-mixed-diet-pi Serum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combined dietary change raised the blood phosphate measurement. organism: Human tissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine experimental_model: Paired 36-hour dietary interventions limitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter. exposure: Low/high phosphate and calcium diets, separated by a week evidence_span: {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"} [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    Complete structured claim and evidence

  3. PTH declined during the higher-phosphate/calcium regimen even while FGF23 increased.

    Paired low/high phosphate and calcium diets in the 2010 study → Serum PTH concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"}
    experimental_model
    Paired 36-hour dietary interventions
    exposure
    Low/high phosphate and calcium diets, separated by a week
    limitations
    Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    Changing calcium alongside phosphate produced a different PTH pattern than a phosphate-only cell challenge.
    primary_references
    [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    tissue_or_cell_type
    Ten healthy adults; serial serum measurements and 24-hour urine

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 972–983

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired 36-hour dietary interventions · source_derived_draft · unverified_draft

    ### phosphorus-mixed-diet-pth PTH declined during the higher-phosphate/calcium regimen even while FGF23 increased. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing calcium alongside phosphate produced a different PTH pattern than a phosphate-only cell challenge. organism: Human tissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine experimental_model: Paired 36-hour dietary interventions limitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter. exposure: Low/high phosphate and calcium diets, separated by a week evidence_span: {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"} [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    Complete structured claim and evidence

  4. Urinary phosphate rose from 21.6 to 28.8 mmol/day during the higher-phosphate/calcium regimen.

    Paired low/high phosphate and calcium diets in the 2010 study → Urinary phosphate excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"}
    experimental_model
    Paired 36-hour dietary interventions
    exposure
    Low/high phosphate and calcium diets, separated by a week
    limitations
    Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    The kidneys excreted more phosphate.
    primary_references
    [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    tissue_or_cell_type
    Ten healthy adults; serial serum measurements and 24-hour urine

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 959–970

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired 36-hour dietary interventions · source_derived_draft · unverified_draft

    ### phosphorus-mixed-diet-urine Urinary phosphate rose from 21.6 to 28.8 mmol/day during the higher-phosphate/calcium regimen. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The kidneys excreted more phosphate. organism: Human tissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine experimental_model: Paired 36-hour dietary interventions limitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter. exposure: Low/high phosphate and calcium diets, separated by a week evidence_span: {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"} [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards