{"id":"09790881-bb7e-59df-9e23-fc86ffdeb47c","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-mixed-diet-pi","predicate":"has_observed_effect","statement":"Serum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ab493ae3-2b7d-56fd-bb16-8e143ed027a2","mechanism_event_label":"The combined dietary change raised the blood phosphate measurement.","subject":{"id":"94692808-d4f8-51f1-9dd3-2bf14daf8116","slug":"high-low-phosphate-calcium-diets","display_name":"Paired low/high phosphate and calcium diets in the 2010 study","entity_type_key":"chemical_species"},"object":{"id":"0e882e8c-b8c4-59e9-b756-28d37b64764e","slug":"serum-inorganic-phosphate","display_name":"Serum inorganic phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ab493ae3-2b7d-56fd-bb16-8e143ed027a2","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-mixed-diet-pi-event","event_type":"observed_intervention","label":"The combined dietary change raised the blood phosphate measurement.","description":"Serum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"99d71198-b9c0-5b54-8906-5abb47c00183","slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"94692808-d4f8-51f1-9dd3-2bf14daf8116","slug":"high-low-phosphate-calcium-diets","display_name":"Paired low/high phosphate and calcium diets in the 2010 study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0e882e8c-b8c4-59e9-b756-28d37b64764e","slug":"serum-inorganic-phosphate","display_name":"Serum inorganic phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/21030580.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\", \"start_char\": 0, \"end_char\": 1603, \"text_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Paired 36-hour dietary interventions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Low/high phosphate and calcium diets, separated by a week","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The combined dietary change raised the blood phosphate measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ten healthy adults; serial serum measurements and 24-hour urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aaefcd3a-0eee-5bd1-9c28-b446118ac31d","evidence_kind":"source_excerpt","locator":"Lines 933-944","start_line":933,"end_line":944,"excerpt":"### phosphorus-mixed-diet-pi\nSerum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The combined dietary change raised the blood phosphate measurement.\norganism: Human\ntissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine\nexperimental_model: Paired 36-hour dietary interventions\nlimitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.\nexposure: Low/high phosphate and calcium diets, separated by a week\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/21030580.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\", \"start_char\": 0, \"end_char\": 1603, \"text_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\"}\n[phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510","model_system":"Paired 36-hour dietary interventions","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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