Serum inorganic phosphate concentration

What acts on it

1. Across dosing-interval midpoints, 94.1% on burosumab versus 7.6% on placebo attained mean serum phosphate above the lower limit of normal.

   Burosumab anti-FGF23 antibody → Serum inorganic phosphate concentration source_derived_draftungraded
   Experimental context and source evidence

   availability_state

   machinery_impairment Imported condition classification; unverified.

   evidence_span

   {"source_cache": "artifacts/phosphorus-research/29947083.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e", "start_char": 0, "end_char": 2327, "text_sha256": "c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e"}

   experimental_model

   Randomized double-blind placebo-controlled phase 3 trial

   exposure

   Burosumab 1 mg/kg or placebo every four weeks; week-24 analysis

   limitations

   FGF23-mediated inherited disease, not simple nutritional deficiency. Pain and function outcomes require multiplicity-adjusted interpretation.

   nutrient_topic

   Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus

   organism

   Human

   plain_language

   Blocking the wasting signal substantially improved the phosphate measurement.

   primary_references

   [phosphorus-p29947083] A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. (2018). https://pubmed.ncbi.nlm.nih.gov/29947083/ DOI: 10.1002/jbmr.3475

   tissue_or_cell_type

   134 symptomatic adults with X-linked hypophosphatemia

   trigger_kind

   machinery_impairment Imported condition classification; unverified.

   Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1193–1204

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled phase 3 trial · source_derived_draft · unverified_draft

   ### phosphorus-burosumab-phosphate Across dosing-interval midpoints, 94.1% on burosumab versus 7.6% on placebo attained mean serum phosphate above the lower limit of normal. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking the wasting signal substantially improved the phosphate measurement. organism: Human tissue_or_cell_type: 134 symptomatic adults with X-linked hypophosphatemia experimental_model: Randomized double-blind placebo-controlled phase 3 trial limitations: FGF23-mediated inherited disease, not simple nutritional deficiency. Pain and function outcomes require multiplicity-adjusted interpretation. exposure: Burosumab 1 mg/kg or placebo every four weeks; week-24 analysis evidence_span: {"source_cache": "artifacts/phosphorus-research/29947083.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e", "start_char": 0, "end_char": 2327, "text_sha256": "c1b305f00a7b9a569ccd197728d942ebbf55f9eaa164a95086d69a34608d3c4e"} [phosphorus-p29947083] A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. (2018). https://pubmed.ncbi.nlm.nih.gov/29947083/ DOI: 10.1002/jbmr.3475

   Complete structured claim and evidence

2. Serum phosphate fell after surgery and during glucose infusion, particularly with continuous glucose administration.

   Postoperative glucose-infusion regimens in the 1989 study → Serum inorganic phosphate concentration source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/phosphorus-research/2741619.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30", "start_char": 0, "end_char": 1180, "text_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30"}

   experimental_model

   Randomized postoperative glucose-infusion timing study

   exposure

   Equal daily glucose supplied continuously versus in five-hour infusions

   limitations

   Acute redistribution and postoperative hypophosphatemia are not synonymous with severe whole-body phosphate depletion.

   nutrient_topic

   Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus

   organism

   Human

   plain_language

   A glucose load can lower the blood phosphate measurement in this clinical context.

   primary_references

   [phosphorus-p2741619] Postoperative and glucose-induced hypophosphatemia in relation to adenosine triphosphate and 2,3-diphosphoglycerate in erythrocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2741619/

   tissue_or_cell_type

   Patients after elective colonic surgery; serum and red cells

   Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1115–1126

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized postoperative glucose-infusion timing study · source_derived_draft · unverified_draft

   ### phosphorus-glucose-pi Serum phosphate fell after surgery and during glucose infusion, particularly with continuous glucose administration. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: A glucose load can lower the blood phosphate measurement in this clinical context. organism: Human tissue_or_cell_type: Patients after elective colonic surgery; serum and red cells experimental_model: Randomized postoperative glucose-infusion timing study limitations: Acute redistribution and postoperative hypophosphatemia are not synonymous with severe whole-body phosphate depletion. exposure: Equal daily glucose supplied continuously versus in five-hour infusions evidence_span: {"source_cache": "artifacts/phosphorus-research/2741619.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30", "start_char": 0, "end_char": 1180, "text_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30"} [phosphorus-p2741619] Postoperative and glucose-induced hypophosphatemia in relation to adenosine triphosphate and 2,3-diphosphoglycerate in erythrocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2741619/

   Complete structured claim and evidence

3. Serum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen.

   Paired low/high phosphate and calcium diets in the 2010 study → Serum inorganic phosphate concentration source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"}

   experimental_model

   Paired 36-hour dietary interventions

   exposure

   Low/high phosphate and calcium diets, separated by a week

   limitations

   Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.

   nutrient_topic

   Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus

   organism

   Human

   plain_language

   The combined dietary change raised the blood phosphate measurement.

   primary_references

   [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510

   tissue_or_cell_type

   Ten healthy adults; serial serum measurements and 24-hour urine

   Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 933–944

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired 36-hour dietary interventions · source_derived_draft · unverified_draft

   ### phosphorus-mixed-diet-pi Serum phosphate rose from 1.11 to 1.32 mmol/L during the higher-phosphate/calcium regimen. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combined dietary change raised the blood phosphate measurement. organism: Human tissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine experimental_model: Paired 36-hour dietary interventions limitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter. exposure: Low/high phosphate and calcium diets, separated by a week evidence_span: {"source_cache": "artifacts/phosphorus-research/21030580.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e", "start_char": 0, "end_char": 1603, "text_sha256": "e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e"} [phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510

   Complete structured claim and evidence

4. The vegetarian diet produced lower serum phosphorus than the meat diet after one week.

   Vegetarian diet in the 2011 CKD crossover trial → Serum inorganic phosphate concentration source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/phosphorus-research/21183586.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660", "start_char": 0, "end_char": 1667, "text_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660"}

   experimental_model

   Randomized-order crossover feeding trial

   exposure

   Seven-day vegetarian and meat diets with equivalent nutrients prepared by research staff

   limitations

   Small short-term CKD study; food source/form matters, but the trial does not isolate one phytate mechanism or establish that all plant phosphate is unabsorbed.

   nutrient_topic

   Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus

   organism

   Human

   plain_language

   Equal listed nutrients did not produce identical blood phosphorus responses.

   primary_references

   [phosphorus-p21183586] Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. (2011). https://pubmed.ncbi.nlm.nih.gov/21183586/ DOI: 10.2215/cjn.05040610

   tissue_or_cell_type

   Nine people with CKD; mean eGFR 32 mL/min

   Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 985–996

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order crossover feeding trial · source_derived_draft · unverified_draft

   ### phosphorus-plant-diet-pi The vegetarian diet produced lower serum phosphorus than the meat diet after one week. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Equal listed nutrients did not produce identical blood phosphorus responses. organism: Human tissue_or_cell_type: Nine people with CKD; mean eGFR 32 mL/min experimental_model: Randomized-order crossover feeding trial limitations: Small short-term CKD study; food source/form matters, but the trial does not isolate one phytate mechanism or establish that all plant phosphate is unabsorbed. exposure: Seven-day vegetarian and meat diets with equivalent nutrients prepared by research staff evidence_span: {"source_cache": "artifacts/phosphorus-research/21183586.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660", "start_char": 0, "end_char": 1667, "text_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660"} [phosphorus-p21183586] Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. (2011). https://pubmed.ncbi.nlm.nih.gov/21183586/ DOI: 10.2215/cjn.05040610

   Complete structured claim and evidence