Vegetarian diet in the 2011 CKD crossover trial: molecular mechanisms & dependencies

How nutrients influence it

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Human evidence only

How nutrients reach it in more than one step

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

The vegetarian diet produced lower FGF23 than the meat diet after one week.
Vegetarian diet in the 2011 CKD crossover trial → Fibroblast growth factor 23 / FGF23 source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/phosphorus-research/21183586.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660", "start_char": 0, "end_char": 1667, "text_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660"}
experimental_model
Randomized-order crossover feeding trial
exposure
Seven-day vegetarian and meat diets with equivalent nutrients prepared by research staff
limitations
Small short-term CKD study; food source/form matters, but the trial does not isolate one phytate mechanism or establish that all plant phosphate is unabsorbed.
nutrient_topic
Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
organism
Human
plain_language
The hormone response also depended on the food source.
primary_references
[phosphorus-p21183586] Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. (2011). https://pubmed.ncbi.nlm.nih.gov/21183586/ DOI: 10.2215/cjn.05040610
tissue_or_cell_type
Nine people with CKD; mean eGFR 32 mL/min
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 998–1009
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order crossover feeding trial · source_derived_draft · unverified_draft
### phosphorus-plant-diet-fgf23 The vegetarian diet produced lower FGF23 than the meat diet after one week. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The hormone response also depended on the food source. organism: Human tissue_or_cell_type: Nine people with CKD; mean eGFR 32 mL/min experimental_model: Randomized-order crossover feeding trial limitations: Small short-term CKD study; food source/form matters, but the trial does not isolate one phytate mechanism or establish that all plant phosphate is unabsorbed. exposure: Seven-day vegetarian and meat diets with equivalent nutrients prepared by research staff evidence_span: {"source_cache": "artifacts/phosphorus-research/21183586.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660", "start_char": 0, "end_char": 1667, "text_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660"} [phosphorus-p21183586] Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. (2011). https://pubmed.ncbi.nlm.nih.gov/21183586/ DOI: 10.2215/cjn.05040610
Complete structured claim and evidence
The vegetarian diet produced lower serum phosphorus than the meat diet after one week.
Vegetarian diet in the 2011 CKD crossover trial → Serum inorganic phosphate concentration source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/phosphorus-research/21183586.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660", "start_char": 0, "end_char": 1667, "text_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660"}
experimental_model
Randomized-order crossover feeding trial
exposure
Seven-day vegetarian and meat diets with equivalent nutrients prepared by research staff
limitations
Small short-term CKD study; food source/form matters, but the trial does not isolate one phytate mechanism or establish that all plant phosphate is unabsorbed.
nutrient_topic
Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
organism
Human
plain_language
Equal listed nutrients did not produce identical blood phosphorus responses.
primary_references
[phosphorus-p21183586] Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. (2011). https://pubmed.ncbi.nlm.nih.gov/21183586/ DOI: 10.2215/cjn.05040610
tissue_or_cell_type
Nine people with CKD; mean eGFR 32 mL/min
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 985–996
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order crossover feeding trial · source_derived_draft · unverified_draft
### phosphorus-plant-diet-pi The vegetarian diet produced lower serum phosphorus than the meat diet after one week. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Equal listed nutrients did not produce identical blood phosphorus responses. organism: Human tissue_or_cell_type: Nine people with CKD; mean eGFR 32 mL/min experimental_model: Randomized-order crossover feeding trial limitations: Small short-term CKD study; food source/form matters, but the trial does not isolate one phytate mechanism or establish that all plant phosphate is unabsorbed. exposure: Seven-day vegetarian and meat diets with equivalent nutrients prepared by research staff evidence_span: {"source_cache": "artifacts/phosphorus-research/21183586.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660", "start_char": 0, "end_char": 1667, "text_sha256": "c1361f250bd0c2febcef675ba888387b4f2ea0b81b171150734d8f148982a660"} [phosphorus-p21183586] Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. (2011). https://pubmed.ncbi.nlm.nih.gov/21183586/ DOI: 10.2215/cjn.05040610
Complete structured claim and evidence

The events it takes part in

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Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

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Open hypotheses

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This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Vegetarian diet in the 2011 CKD crossover trial