{"id":"fb708847-b4eb-5595-b760-62ba0bb8c31a","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-diet-renal-feedback","predicate":"is_associated_with","statement":"Diet-related FGF23 changes correlated inversely with maximal tubular phosphate reabsorption and calcitriol, and positively with urinary phosphate excretion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9b3b820b-8ed2-583b-8137-1415088f1100","mechanism_event_label":"The hormone, kidney and vitamin D responses moved together during the intervention.","subject":{"id":"99d71198-b9c0-5b54-8906-5abb47c00183","slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"},"object":{"id":"d5440699-39d4-5b98-b828-4e1d63138882","slug":"renal-phosphate-reabsorption","display_name":"Renal phosphate reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9b3b820b-8ed2-583b-8137-1415088f1100","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-diet-renal-feedback-event","event_type":"observed_intervention","label":"The hormone, kidney and vitamin D responses moved together during the intervention.","description":"Diet-related FGF23 changes correlated inversely with maximal tubular phosphate reabsorption and calcitriol, and positively with urinary phosphate excretion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6edbc5a6-fcb5-516d-9c86-66950a8984b3","slug":"fgf23","display_name":"Fibroblast growth factor 23 / FGF23","entity_type_key":"protein"},"role":"correlated_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"91a16b02-ae37-5df7-976f-d6cd54b58cda","slug":"circulating-calcitriol-concentration","display_name":"Circulating calcitriol concentration","entity_type_key":"cellular_process"},"role":"correlated_measurement","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"99d71198-b9c0-5b54-8906-5abb47c00183","slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d5440699-39d4-5b98-b828-4e1d63138882","slug":"renal-phosphate-reabsorption","display_name":"Renal phosphate reabsorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/15613425.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2\", \"start_char\": 0, \"end_char\": 1563, \"text_sha256\": \"4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled sequential dietary intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Phosphate intake and calcium/binder cointerventions are explicit; correlation of hormones with renal handling does not independently prove each mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The hormone, kidney and vitamin D responses moved together during the intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. (2005). https://pubmed.ncbi.nlm.nih.gov/15613425/ DOI: 10.1210/jc.2004-1039","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"29 healthy young men; serum hormones and renal handling","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a5927125-c869-58c0-b9e6-c357b8a1f9fa","evidence_kind":"source_excerpt","locator":"Lines 920-931","start_line":920,"end_line":931,"excerpt":"### phosphorus-diet-renal-feedback\nDiet-related FGF23 changes correlated inversely with maximal tubular phosphate reabsorption and calcitriol, and positively with urinary phosphate excretion.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The hormone, kidney and vitamin D responses moved together during the intervention.\norganism: Human\ntissue_or_cell_type: 29 healthy young men; serum hormones and renal handling\nexperimental_model: Controlled sequential dietary intervention\nlimitations: Phosphate intake and calcium/binder cointerventions are explicit; correlation of hormones with renal handling does not independently prove each mediator.\nexposure: Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/15613425.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2\", \"start_char\": 0, \"end_char\": 1563, \"text_sha256\": \"4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2\"}\n[phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. 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