{"id":"502c1054-3457-5211-8bf7-ddc77c14e16b","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-mixed-diet-fgf23","predicate":"has_observed_effect","statement":"Intact FGF23 rose from 33 to 37 ng/L during the higher-phosphate/calcium regimen.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"35cdb40f-d03c-57da-8852-a9e336adb7f9","mechanism_event_label":"The active hormone concentration also increased.","subject":{"id":"94692808-d4f8-51f1-9dd3-2bf14daf8116","slug":"high-low-phosphate-calcium-diets","display_name":"Paired low/high phosphate and calcium diets in the 2010 study","entity_type_key":"chemical_species"},"object":{"id":"fe53ea97-98c6-5545-a40f-d4e43129d32d","slug":"circulating-intact-fgf23","display_name":"Circulating biologically active intact FGF23","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"35cdb40f-d03c-57da-8852-a9e336adb7f9","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-mixed-diet-fgf23-event","event_type":"observed_intervention","label":"The active hormone concentration also increased.","description":"Intact FGF23 rose from 33 to 37 ng/L during the higher-phosphate/calcium regimen.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"99d71198-b9c0-5b54-8906-5abb47c00183","slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"94692808-d4f8-51f1-9dd3-2bf14daf8116","slug":"high-low-phosphate-calcium-diets","display_name":"Paired low/high phosphate and calcium diets in the 2010 study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fe53ea97-98c6-5545-a40f-d4e43129d32d","slug":"circulating-intact-fgf23","display_name":"Circulating biologically active intact FGF23","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/21030580.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\", \"start_char\": 0, \"end_char\": 1603, \"text_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Paired 36-hour dietary interventions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Low/high phosphate and calcium diets, separated by a week","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The active hormone concentration also increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ten healthy adults; serial serum measurements and 24-hour urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d5445bad-8207-5bc0-938b-a587153873d1","evidence_kind":"source_excerpt","locator":"Lines 946-957","start_line":946,"end_line":957,"excerpt":"### phosphorus-mixed-diet-fgf23\nIntact FGF23 rose from 33 to 37 ng/L during the higher-phosphate/calcium regimen.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The active hormone concentration also increased.\norganism: Human\ntissue_or_cell_type: Ten healthy adults; serial serum measurements and 24-hour urine\nexperimental_model: Paired 36-hour dietary interventions\nlimitations: Both calcium and phosphate changed; phosphate alone cannot be assigned the full effect. Timing and circadian variation matter.\nexposure: Low/high phosphate and calcium diets, separated by a week\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/21030580.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\", \"start_char\": 0, \"end_char\": 1603, \"text_sha256\": \"e51a1cd580ac4ea7b0232f65c73ac0814df6bff655bf7bd6d0d82f7f9f21a33e\"}\n[phosphorus-p21030580] Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. (2011). https://pubmed.ncbi.nlm.nih.gov/21030580/ DOI: 10.2215/cjn.04730510","model_system":"Paired 36-hour dietary interventions","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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