{"id":"fcb1ac70-bc95-5248-bc35-535208a950df","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-diet-fgf23","predicate":"modulates","statement":"Reported serum FGF23 decreased during low-phosphate feeding and increased after oral phosphate loading in healthy men.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b6936c38-d8c8-5b67-9cbf-4e2f7139d876","mechanism_event_label":"Changing phosphorus exposure changed a hormone involved in phosphate handling.","subject":{"id":"99d71198-b9c0-5b54-8906-5abb47c00183","slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"},"object":{"id":"33cdba76-34ad-5f62-9c38-f208e2e3623a","slug":"circulating-fgf23-assay-result","display_name":"Circulating FGF23 assay result, molecular form unresolved","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b6936c38-d8c8-5b67-9cbf-4e2f7139d876","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-diet-fgf23-event","event_type":"observed_intervention","label":"Changing phosphorus exposure changed a hormone involved in phosphate handling.","description":"Reported serum FGF23 decreased during low-phosphate feeding and increased after oral phosphate loading in healthy men.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"99d71198-b9c0-5b54-8906-5abb47c00183","slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"33cdba76-34ad-5f62-9c38-f208e2e3623a","slug":"circulating-fgf23-assay-result","display_name":"Circulating FGF23 assay result, molecular form unresolved","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/15613425.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2\", \"start_char\": 0, \"end_char\": 1563, \"text_sha256\": \"4a8c4110b9c57e9f8f54305eb77abb80dd90253fc99e2f5aa21a4a3f129983c2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled sequential dietary intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Five-day low-phosphate diet plus binder, then phosphate loading; calcium adjusted to minimize PTH changes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"FGF23 assay form not resolved from the indexed abstract; circulating FGF23 result must not be read as a quantified cleavage ratio.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"object_scope","value_text":"FGF23 assay result; assay form unresolved from abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Changing phosphorus exposure changed a hormone involved in phosphate handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p15613425] Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. 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