Component

Human plasma exposure to lovastatin

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Gemfibrozil did not significantly change parent lovastatin pharmacokinetic parameters in that LipoCol Forte experiment.

    Gemfibrozil → Human plasma exposure to lovastatin source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text PMC3513969
    experimental_model
    Same 13 volunteers and dosing protocol.
    limitations
    The positive acid result must not be generalized to every measured chemical form.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The lactone and acid did not show the same interaction result.
    primary_references
    [23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 172–178

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same 13 volunteers and dosing protocol. · source_derived_draft · unverified_draft

    ## red-yeast-rice-gemfibrozil-lactone-null The lactone and acid did not show the same interaction result. Gemfibrozil did not significantly change parent lovastatin pharmacokinetic parameters in that LipoCol Forte experiment. Model: Same 13 volunteers and dosing protocol. Limitations: The positive acid result must not be generalized to every measured chemical form. Evidence access: Primary full text PMC3513969 [23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043
    Complete structured claim and evidence

  2. Repeated double-strength grapefruit juice increased lovastatin peak concentration about 12-fold and exposure area about 15-fold after an 80 mg dose in ten volunteers.

    Double-strength grapefruit juice in the 1998 lovastatin study → Human plasma exposure to lovastatin source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Randomized crossover: 200 mL three times daily for two days, with further juice around the day-three dose.
    limitations
    Prescription lovastatin and intensive juice regimen; not a measured red yeast rice interaction or a multiplier for ordinary juice intake.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    Food-related inhibition of first-pass handling can change drug exposure.
    primary_references
    [9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 180–186

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized crossover: 200 mL three times daily for two days, with further juice around the day-three dose. · source_derived_draft · unverified_draft

    ## red-yeast-rice-grapefruit-lovastatin Food-related inhibition of first-pass handling can change drug exposure. Repeated double-strength grapefruit juice increased lovastatin peak concentration about 12-fold and exposure area about 15-fold after an 80 mg dose in ten volunteers. Model: Randomized crossover: 200 mL three times daily for two days, with further juice around the day-three dose. Limitations: Prescription lovastatin and intensive juice regimen; not a measured red yeast rice interaction or a multiplier for ordinary juice intake. Evidence access: Primary abstract [9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0
    Complete structured claim and evidence

  3. Itraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers.

    Itraconazole → Human plasma exposure to lovastatin source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased.
    limitations
    The numerical magnitude belongs to this drug regimen, not to untested red yeast rice preparations.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    A drug interaction can substantially change constituent exposure.
    primary_references
    [9690949] Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9690949/ · DOI 10.1046/j.1365-2125.1998.00034.x

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 196–202

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased. · source_derived_draft · unverified_draft

    ## red-yeast-rice-itraconazole A drug interaction can substantially change constituent exposure. Itraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers. Model: Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased. Limitations: The numerical magnitude belongs to this drug regimen, not to untested red yeast rice preparations. Evidence access: Primary abstract [9690949] Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9690949/ · DOI 10.1046/j.1365-2125.1998.00034.x
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. In 14 volunteers, single doses of one, two or four LipoCol Forte capsules produced dose-related lovastatin and lovastatin-acid exposure; one capsule twice daily for five days produced no significant accumulation.

    LipoCol Forte red yeast rice preparation studied in 2012 → Human plasma exposure to lovastatin hydroxy acid source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary full text PMC3513969
    experimental_model
    Human fed-state dose and repeat-dose study; 600 mg per capsule.
    limitations
    Does not establish identical kinetics for other formulations, chronic use or interacting-drug conditions.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The measured product had a defined short-term exposure profile.
    primary_references
    [23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 148–154

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human fed-state dose and repeat-dose study; 600 mg per capsule. · source_derived_draft · unverified_draft

    ## red-yeast-rice-lipocol-dose-response The measured product had a defined short-term exposure profile. In 14 volunteers, single doses of one, two or four LipoCol Forte capsules produced dose-related lovastatin and lovastatin-acid exposure; one capsule twice daily for five days produced no significant accumulation. Model: Human fed-state dose and repeat-dose study; 600 mg per capsule. Limitations: Does not establish identical kinetics for other formulations, chronic use or interacting-drug conditions. Evidence access: Primary full text PMC3513969 [23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards