Component
Itraconazole
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Itraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased.
- limitations
- The numerical magnitude belongs to this drug regimen, not to untested red yeast rice preparations.
- nutrient_topic
- Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
- plain_language
- A drug interaction can substantially change constituent exposure.
- primary_references
- [9690949] Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9690949/ · DOI 10.1046/j.1365-2125.1998.00034.x
Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 196–202
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased. · source_derived_draft · unverified_draft
## red-yeast-rice-itraconazole A drug interaction can substantially change constituent exposure. Itraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers. Model: Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased. Limitations: The numerical magnitude belongs to this drug regimen, not to untested red yeast rice preparations. Evidence access: Primary abstract [9690949] Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9690949/ · DOI 10.1046/j.1365-2125.1998.00034.x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.