{"id":"bf3ec66f-196c-50ac-be96-4686f6821cab","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-itraconazole","predicate":"increases_tested","statement":"Itraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c72282af-908f-58b7-824c-97fa1cb6bada","mechanism_event_label":"A drug interaction can substantially change constituent exposure.","subject":{"id":"15414c54-a6b4-506e-8ea5-628c0d6276ce","slug":"itraconazole","display_name":"Itraconazole","entity_type_key":"drug"},"object":{"id":"d4154949-85ce-5c98-9f32-af94e72d613a","slug":"human-lovastatin-plasma-exposure","display_name":"Human plasma exposure to lovastatin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c72282af-908f-58b7-824c-97fa1cb6bada","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-itraconazole-event","event_type":"observed_relationship","label":"A drug interaction can substantially change constituent exposure.","description":"Itraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15414c54-a6b4-506e-8ea5-628c0d6276ce","slug":"itraconazole","display_name":"Itraconazole","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d4154949-85ce-5c98-9f32-af94e72d613a","slug":"human-lovastatin-plasma-exposure","display_name":"Human plasma exposure to lovastatin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bd3bb602-9a12-5d58-8130-538236270e6f","slug":"lovastatin-acid","display_name":"Lovastatin hydroxy acid / monacolin KA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"54e95ff1-4ffa-5e6f-a4cb-b47e5d2a5bda","slug":"cyp3a4","display_name":"Human cytochrome P450 3A4","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The numerical magnitude belongs to this drug regimen, not to untested red yeast rice preparations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A drug interaction can substantially change constituent exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[9690949] Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9690949/ · DOI 10.1046/j.1365-2125.1998.00034.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"04835daa-e359-5607-9258-c492ce06fc45","evidence_kind":"source_excerpt","locator":"Lines 196-202","start_line":196,"end_line":202,"excerpt":"## red-yeast-rice-itraconazole\nA drug interaction can substantially change constituent exposure.\nItraconazole 100 mg daily for four days increased lovastatin peak concentration about 15-fold and exposure area more than 15-fold after a 40 mg dose in ten volunteers.\nModel: Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased.\nLimitations: The numerical magnitude belongs to this drug regimen, not to untested red yeast rice preparations.\nEvidence access: Primary abstract\n[9690949] Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9690949/ · DOI 10.1046/j.1365-2125.1998.00034.x","model_system":"Randomized crossover prescription-lovastatin study; lovastatin-acid exposure also increased.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}