Component

Double-strength grapefruit juice in the 1998 lovastatin study

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. In the same experiment, lovastatin-acid peak concentration rose about fourfold and exposure area about fivefold.

    Double-strength grapefruit juice in the 1998 lovastatin study → Human plasma exposure to lovastatin hydroxy acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Ten healthy volunteers; 80 mg prescription lovastatin.
    limitations
    First-pass CYP3A4 inhibition was the proposed explanation, not a measured effect on all red yeast rice products.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    The two chemical forms had different exposure changes.
    primary_references
    [9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 188–194

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Ten healthy volunteers; 80 mg prescription lovastatin. · source_derived_draft · unverified_draft

    ## red-yeast-rice-grapefruit-acid The two chemical forms had different exposure changes. In the same experiment, lovastatin-acid peak concentration rose about fourfold and exposure area about fivefold. Model: Ten healthy volunteers; 80 mg prescription lovastatin. Limitations: First-pass CYP3A4 inhibition was the proposed explanation, not a measured effect on all red yeast rice products. Evidence access: Primary abstract [9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0
    Complete structured claim and evidence

  2. Repeated double-strength grapefruit juice increased lovastatin peak concentration about 12-fold and exposure area about 15-fold after an 80 mg dose in ten volunteers.

    Double-strength grapefruit juice in the 1998 lovastatin study → Human plasma exposure to lovastatin source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Randomized crossover: 200 mL three times daily for two days, with further juice around the day-three dose.
    limitations
    Prescription lovastatin and intensive juice regimen; not a measured red yeast rice interaction or a multiplier for ordinary juice intake.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    Food-related inhibition of first-pass handling can change drug exposure.
    primary_references
    [9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 180–186

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized crossover: 200 mL three times daily for two days, with further juice around the day-three dose. · source_derived_draft · unverified_draft

    ## red-yeast-rice-grapefruit-lovastatin Food-related inhibition of first-pass handling can change drug exposure. Repeated double-strength grapefruit juice increased lovastatin peak concentration about 12-fold and exposure area about 15-fold after an 80 mg dose in ten volunteers. Model: Randomized crossover: 200 mL three times daily for two days, with further juice around the day-three dose. Limitations: Prescription lovastatin and intensive juice regimen; not a measured red yeast rice interaction or a multiplier for ordinary juice intake. Evidence access: Primary abstract [9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards