{"id":"e45ad010-4408-5721-8ce0-ed4028e4fb8f","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-grapefruit-acid","predicate":"increases_tested","statement":"In the same experiment, lovastatin-acid peak concentration rose about fourfold and exposure area about fivefold.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"456d2f45-2525-50eb-b824-658291b0eecf","mechanism_event_label":"The two chemical forms had different exposure changes.","subject":{"id":"9866945f-c9c2-52b1-aca1-9fff5b57e60d","slug":"double-strength-grapefruit-juice","display_name":"Double-strength grapefruit juice in the 1998 lovastatin study","entity_type_key":"chemical_species"},"object":{"id":"5dcb50cd-6f97-5bb5-806c-277c8a5fed88","slug":"human-lovastatin-acid-plasma-exposure","display_name":"Human plasma exposure to lovastatin hydroxy acid","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"456d2f45-2525-50eb-b824-658291b0eecf","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-grapefruit-acid-event","event_type":"observed_relationship","label":"The two chemical forms had different exposure changes.","description":"In the same experiment, lovastatin-acid peak concentration rose about fourfold and exposure area about fivefold.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9866945f-c9c2-52b1-aca1-9fff5b57e60d","slug":"double-strength-grapefruit-juice","display_name":"Double-strength grapefruit juice in the 1998 lovastatin study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dcb50cd-6f97-5bb5-806c-277c8a5fed88","slug":"human-lovastatin-acid-plasma-exposure","display_name":"Human plasma exposure to lovastatin hydroxy acid","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bd3bb602-9a12-5d58-8130-538236270e6f","slug":"lovastatin-acid","display_name":"Lovastatin hydroxy acid / monacolin KA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten healthy volunteers; 80 mg prescription lovastatin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"First-pass CYP3A4 inhibition was the proposed explanation, not a measured effect on all red yeast rice products.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The two chemical forms had different exposure changes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d6fea68d-ce2d-5340-85ae-7b11306f2b36","evidence_kind":"source_excerpt","locator":"Lines 188-194","start_line":188,"end_line":194,"excerpt":"## red-yeast-rice-grapefruit-acid\nThe two chemical forms had different exposure changes.\nIn the same experiment, lovastatin-acid peak concentration rose about fourfold and exposure area about fivefold.\nModel: Ten healthy volunteers; 80 mg prescription lovastatin.\nLimitations: First-pass CYP3A4 inhibition was the proposed explanation, not a measured effect on all red yeast rice products.\nEvidence access: Primary abstract\n[9585793] Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9585793/ · DOI 10.1016/S0009-9236(98)90034-0","model_system":"Ten healthy volunteers; 80 mg prescription lovastatin.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}